論文

国際誌
2021年1月14日

Alterations in Glucose Metabolism Due to Decreased Expression of Heterogeneous Nuclear Ribonucleoprotein M in Pancreatic Ductal Adenocarcinoma.

Biology
  • Jun-Ichi Takino
  • ,
  • Takuma Sato
  • ,
  • Isamu Hiraishi
  • ,
  • Kentaro Nagamine
  • ,
  • Takamitsu Hori

10
1
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/biology10010057

The prognosis of pancreatic cancer is considerably worse than that of other cancers, as early detection of pancreatic cancer is difficult and due to its hypovascular environment, which involves low blood flow and a low supply of oxygen and nutrients. Moreover, pancreatic cancer demonstrates a mechanism that allows it to survive in a hypovascular environment. However, the detailed mechanism remains elusive. Recently, it has been reported that heterogeneous ribonuclear protein M (HNRNPM) is a splicing factor associated with malignant tumors. Thus, in this study, we investigated the expression and effects of HNRNPM in pancreatic ductal adenocarcinoma (PDA). We observed that HNRNPM expression, which is highly expressed in pancreatic tissues, was reduced in PDA tissues. Additionally, knockdown of HNRNPM under low-glucose conditions that mimic a hypovascular environment was shown to alter glucose metabolism and prolong cell survival by suppressing glucose consumption. These results suggest that the decreased expression of HNRNPM in PDA may be involved in its adaptation to a hypovascular environment.

リンク情報
DOI
https://doi.org/10.3390/biology10010057
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33466816
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830884
ID情報
  • DOI : 10.3390/biology10010057
  • PubMed ID : 33466816
  • PubMed Central 記事ID : PMC7830884

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