Takino Junichi

Profile Information

Affiliation: Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences, Hiroshima International University

J-GLOBAL ID: 201901008119374746
researchmap Member ID: B000380355

Research Areas

Life sciences / Molecular biology /

Papers

RasGRP2 Attenuates Oxygen Deprivation-Induced Autophagy in Vascular Endothelial Cells

Shouhei Miyazaki, Jun-ichi Takino, Kentaro Nagamine, Takamitsu Hori

Biological and Pharmaceutical Bulletin, 46(11) 1512-1516, Nov 1, 2023
Effects of Toxic AGEs (TAGE) on Human Health

Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Yoshiki Koriyama

Cells, 11(14) 2178-2178, Jul 12, 2022
The Role of RASGRP2 in Vascular Endothelial Cells-A Mini Review.

Jun-Ichi Takino, Shouhei Miyazaki, Kentaro Nagamine, Takamitsu Hori

International journal of molecular sciences, 22(20), Oct 15, 2021
Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage

Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Yoshiki Koriyama, Chigusa Kikuchi, Ayako Furukawa, Kentaro Nagamine, Takamitsu Hori, Tamihide Matsunaga

Biomolecules, 11(3) 387-387, Mar 5, 2021
細胞内Toxic AGEs(TAGE)の生成・蓄積は各種細胞障害のトリガーとなる

竹内正義, 逆井亜紀子[坂井], 高田尊信, 瀧野純一, 郡山恵樹, 菊池千草, 古川絢子, 長嶺憲太郎, 堀隆光, 松永民秀

日本薬学会年会要旨集, 141年会 28P02-235, Mar, 2021
RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells.

Jun-Ichi Takino, Takuma Sato, Takumi Kanetaka, Kasumi Okihara, Kentaro Nagamine, Masayoshi Takeuchi, Takamitsu Hori

Scientific reports, 11(1) 2959-2959, Feb 3, 2021
Alterations in Glucose Metabolism Due to Decreased Expression of Heterogeneous Nuclear Ribonucleoprotein M in Pancreatic Ductal Adenocarcinoma.

Jun-Ichi Takino, Takuma Sato, Isamu Hiraishi, Kentaro Nagamine, Takamitsu Hori

Biology, 10(1), Jan 14, 2021
Suppression of Hepatic Stellate Cell Death by Toxic Advanced Glycation End-Products.

Jun-Ichi Takino, Takuma Sato, Kentaro Nagamine, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Takamitsu Hori

Biological & pharmaceutical bulletin, 44(1) 112-117, 2021
The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells.

Takino JI, Sato T, Nagamine K, Hori T

Scientific reports, 9(1) 16717-16717, Nov, 2019 Peer-reviewed
Evidence for Toxic Advanced Glycation End-Products Generated in the Normal Rat Liver

Takanobu Takata, Akiko Sakasai-Sakai, Jun-ichi Takino, Masayoshi Takeuchi

Nutrients, 11(7) 1612-1612, Jul 16, 2019 Peer-reviewed
The Relevance of Toxic AGEs (TAGE) Cytotoxicity to NASH Pathogenesis: A Mini-Review

Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Masayoshi Takeuchi

Nutrients, 11(2) 462-462, Feb 22, 2019 Peer-reviewed
RASGRP2 Suppresses Apoptosis via Inhibition of ROS Production in Vascular Endothelial Cells.

Sato T, Takino JI, Nagamine K, Nishio K, Hori T

TheScientificWorldJournal, 2019 4639165-4639165, 2019 Peer-reviewed
Toxic AGEs (TAGE) theory for pathophysiology of the onset / progression of NAFLD and ALD

Akiko Sakasai-Sakai, Jun-ichi Takano, Atsushi Fukumura, Takanobu Takata, Mikihiro Tsutsumi, Masayoshi Takeuchi

The journal of Japan Mibyo System Association, 24(1) 19-25, Mar, 2018 Peer-reviewed
Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death

Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Masayoshi Takeuchi

SCIENTIFIC REPORTS, 7(1) 14282, Oct, 2017 Peer-reviewed
Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD

Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi

NUTRIENTS, 9(6), Jun, 2017 Peer-reviewed
Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function

American journal of molecular biology, 7(2) 87-98, Apr, 2017 Peer-reviewed
Involvement of toxic AGEs(TAGE) in the onset / progrssion of nonalcoholic fatty liver disease (NAFLD): A novel prevention strategy

Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata

23(1) 20-30, 2017
Glycer-AGEsによる神経細胞障害とアルツハイマー病バイオマーカー変化

郡山恵樹, 古川絢子, 瀧野純一, 竹内正義

日本薬学会年会要旨集, 136年会(4) 207-207, Mar, 2016
Assessment of Total Sugar and Glucose Concentrations in Commonly Consumed Beverages in Japan

1(2), Dec, 2015 Peer-reviewed
Glyceraldehyde caused Alzheimer's disease-like alterations in diagnostic marker levels in SH-SY5Y human neuroblastoma cells

Yoshiki Koriyama, Ayako Furukawa, Michiru Muramatsu, Jun-ichi Takino, Masayoshi Takeuchi

SCIENTIFIC REPORTS, 5 13313, Aug, 2015 Peer-reviewed

Misc.

Suppression of inflammation-related genes by RASGRP2 in the vascular endothelial cells

高橋のどか, 瀧野純一, 宮崎翔平, 長嶺憲太郎, 堀隆光

日本薬学会年会要旨集(Web), 142nd, 2022
Toxic AGEs (TAGE) as a new concept in the lifestyle-related diseases

竹内正義, 逆井(坂井)亜紀子, 高田尊信, 瀧野純一, 郡山恵樹, 古川絢子, 那須隆斗, 菊池千草, 長嶺憲太郎, 堀隆光 …

日本薬学会年会要旨集(Web), 142nd, 2022
Intracellular localization analysis of HNRNPM in the human pancreatic cancer cell lines

森澤彩乃, 瀧野純一, 宮崎翔平, 長嶺憲太郎, 堀隆光

日本薬学会年会要旨集(Web), 142nd, 2022
The alters in glucose metabolism due to decreased expression of HNRNPM in pancreatic duct adenocarcinoma

瀧野純一, 佐藤拓真, 長嶺憲太郎, 堀隆光

日本薬学会年会要旨集(Web), 141st, 2021
Suppression of RasGRP2 on enhanced vascular permeability by advanced glycation end products

堀隆光, 佐藤拓真, 長嶺憲太郎, 竹内正義, 瀧野純一

日本薬学会年会要旨集(Web), 141st, 2021
Suppression of autophagy by RASGRP2 in vascular endothelial cells

佐藤拓真, 瀧野純一, 長嶺憲太郎, 堀隆光

日本薬学会年会要旨集(Web), 141st, 2021
低濃度グルコース条件下にある膵臓がんにおけるHNRNPM発現減少の影響

佐藤拓真, 瀧野純一, 長嶺憲太郎, 堀隆光

日本生化学会大会(Web), 93rd, 2020
The mechanism of apoptosis suppression by RasGRP2 in vascular endothelial cells

瀧野純一, 佐藤拓真, 長嶺憲太郎, 堀隆光

日本薬学会年会要旨集(CD-ROM), 140th, 2020
Effect of RasGRP2 on enhanced vascular permeability by advanced glycation end products

堀隆光, 長嶺憲太郎, 竹内正義, 瀧野純一

日本薬学会年会要旨集(CD-ROM), 140th, 2020
糖化によるNASH発症に関わる遺伝子の探索

瀧野純一, 堀隆光, 長嶺憲太郎

Bio Clinica, 34(12), 2019
肝星細胞の活性化における終末糖化産物(AGEs)の細胞死抑制

瀧野純一, 長嶺憲太郎, 佐藤拓真, 竹内正義, 堀隆光

日本薬学会年会要旨集(CD-ROM), 139th, 2019
血管内皮細胞におけるR-Ras-PI3K-Aktシグナル経路を介したRasGRP2によるBax活性化アポトーシスの阻害

瀧野純一, 佐藤拓真, 長嶺憲太郎, 長嶺憲太郎, 堀隆光

日本分子生物学会年会プログラム・要旨集(Web), 42nd, 2019
RNA結合蛋白質HNRNPMのノックダウンによる下流遺伝子の網羅的解析

長嶺憲太郎, 瀧野純一, 和氣亜莉沙, 安田華織子, 竹内正義, 堀隆光

日本薬学会年会要旨集(CD-ROM), 138th, 2018
肝星細胞の活性化における終末糖化産物(AGEs)の影響

瀧野純一, 長嶺憲太郎, 佐藤拓真, 竹内正義, 堀隆光

日本薬学会年会要旨集(CD-ROM), 138th, 2018
HNRNPMノックダウンによる遺伝子発現変化の解析~リキッドバイオプシーによる非アルコール性脂肪肝炎の診断を目指して~

鈴木美琴, 長嶺憲太郎, 瀧野純一, 佐藤拓真, 竹内正義, 堀隆光

日本薬学会年会要旨集(CD-ROM), 137th, 2017
Ras guanyl releasing protein2(RASGRP2)による血管内皮細胞死の抑制

佐藤拓真, 瀧野純一, 長嶺憲太郎, 堀隆光

日本薬学会年会要旨集(CD-ROM), 137th, 2017
糖化HNRNPMによる遺伝子発現変化の解析

長嶺憲太郎, 瀧野純一, 永井真也, 山根惇, 平石勇, 竹内正義, 堀隆光

日本薬学会年会要旨集(CD-ROM), 136th, 2016
飲食物中AGEs及び糖毒性の真実現代の食生活に潜む落とし穴

竹内正義, 古野理美, 白井ひかり, 河上美穂子, 村松充, 小林由佳, 山岸昌一, 瀧野純一

日本抗加齢医学会総会プログラム・抄録集, 15回 207-207, May, 2015
飲食物中AGEs及び糖毒性の真実新たな食事指導の概念

竹内正義, 瀧野純一, 古野理美, 小林由佳, 白井ひかり, 河上美穂子, 村松充, 山岸昌一

糖尿病, 58(Suppl.1) S-217, Apr, 2015
糖化のターゲット蛋白質であるhnRNPMの解析

山根惇, 永井真也, 瀧野純一, 長嶺憲太郎, 竹内正義, 堀隆光

日本薬学会年会要旨集(CD-ROM), 135th, 2015

Research Projects

生活習慣病の新規概念「毒性終末糖化産物（Toxic AGEs）原因説」の確立

科学研究費助成事業, 基盤研究(A), 日本学術振興会, Apr, 2021 - Mar, 2025

竹内正義, 石垣靖人, 松永民秀, 郡山恵樹, 瀧野純一
The effects of HNRNPM in pancreatic cancer under the hypovascular environment

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Takino Junichi
Generation and accumulation of intracellular toxic advanced glycation end-products due to modern dietary habits and elucidation of relevant cytotoxic mechanisms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2020

TAKEUCHI Masayoshi
Association between characteristics of current diet and onset/deterioration of non-alcoholic fatty liver disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

TAKEUCHI Masayoshi, TAKINO Jun-ichi, TAKATA Takanobu, UEDA Tadashi
1nvolvement of hyperglycemiaand dietary AGEs inthe prevention of life style-related disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

TAKEUCHI Masayoshi, TAKINO Jun-ichi
Involvement of dietary AGEs in the life style-related disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2008

TAKEUCHI Masayoshi, SATO Takashi, TAKINO Jun-ichi

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