Takashi Kinoshita

Profile Information

Affiliation: Hospital, Chiba University

Researcher number: 00648462
J-GLOBAL ID: 201801011794253641
researchmap Member ID: B000336399

Research Interests

Research Areas

Life sciences / Otorhinolaryngology /

Papers

MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway.

Alimasi Aersilan, Naoko Hashimoto, Kazuyuki Yamagata, Masataka Yokoyama, Akitoshi Nakayama, Xiaoyan Shi, Hidekazu Nagano, Ikki Sakuma, Nijiro Nohata, Takashi Kinoshita …

Scientific reports, 12(1) 18443-18443, Nov 2, 2022
Noteworthy Factors to Decide Therapeutic Strategy for Carcinoma ex Pleomorphic Adenoma of Parotid Gland: A Preliminary Study Statistical Analysis of 22 Cases from Single Institution.

Kosei Mori, Kazuki Yamasaki, Yuki Morimoto, Takashi Kinoshita, Shunichi Asai, Tomoyuki Arai, Tomohisa Iinuma, Syuji Yonekura, Toyoyuki Hanazawa

Life (Basel, Switzerland), 12(11), Oct 24, 2022
癌抑制型microRNA-199-familyにより制御される新規癌促進型遺伝子の探索

田中希, 峯村周, 浅井俊一, 駒綾香, 吉川直子, 木下崇, 笠松厚志, 花澤豊行, 鵜澤一弘

頭頸部癌, 48(2) 213-213, May, 2022
Impact of miR-1/miR-133 Clustered miRNAs: PFN2 Facilitates Malignant Phenotypes in Head and Neck Squamous Cell Carcinoma.

Shunichi Asai, Ayaka Koma, Nijiro Nohata, Takashi Kinoshita, Naoko Kikkawa, Mayuko Kato, Chikashi Minemura, Katsuhiro Uzawa, Toyoyuki Hanazawa, Naohiko Seki

Biomedicines, 10(3), Mar 12, 2022
AYA世代に生じた滑膜肉腫の2症例

茂木愛, 茶薗英明, 越塚慶一, 木下崇, 山崎一樹, 吉川直子, 花澤豊行

頭頸部癌, 47(4) 400-405, Dec, 2021
Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma

Nozomi Tanaka, Chikashi Minemura, Shunichi Asai, Naoko Kikkawa, Takashi Kinoshita, Sachi Oshima, Ayaka Koma, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa …

Genes, 12(12) 1910-1910, Nov 27, 2021
がん遺伝子パネル検査を契機に病理診断が修正された中咽頭明細胞癌の1例

越塚慶一, 山崎一樹, 木下崇, 飯沼智久, 米倉修二, 花澤豊行

頭頸部癌, 47(3) 342-347, Oct, 2021
Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma.

Ayaka Koma, Shunichi Asai, Chikashi Minemura, Sachi Oshima, Takashi Kinoshita, Naoko Kikkawa, Keiichi Koshizuka, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa …

International journal of molecular sciences, 22(18), Sep 14, 2021
Identification of Tumor Suppressive Genes Regulated by miR-31-5p and miR-31-3p in Head and Neck Squamous Cell Carcinoma.

Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa …

International journal of molecular sciences, 22(12), Jun 8, 2021
癌抑制型microRNA(miR-139-5p/miR-139-3p)が制御する頭頸部扁平上皮癌・癌促進型遺伝子の探索

駒綾香, 浅井俊一, 峯村周, 越塚慶一, 木下崇, 笠松厚志, 横江秀隆, 花澤豊行, 鵜澤一弘

頭頸部癌, 47(2) 228-228, May, 2021
ニボルマブの効果予測因子の検討

木下崇, 腰塚慶一, 山崎一樹, 花澤豊行

頭頸部癌, 46(2) 150-150, Jul, 2020
ニボルマブ投与が原因で表皮壊死症を発症した舌癌の1例

砂金美紀, 越塚慶一, 木下崇, 山崎一樹, 櫻井大樹, 花澤豊行

頭頸部癌, 46(2) 150-150, Jul, 2020
AYA世代に生じた滑膜肉腫の2症例

茂木愛, 茶薗英明, 越塚慶一, 木下崇, 山埼一樹, 花澤豊行

頭頸部癌, 46(2) 165-165, Jul, 2020
Regulation of Oncogenic Targets by miR-99a-3p (Passenger Strand of miR-99a-Duplex) in Head and Neck Squamous Cell Carcinoma.

Okada R, Koshizuka K, Yamada Y, Moriya S, Kikkawa N, Kinoshita T, Hanazawa T, Seki N

Cells, 8(12), Nov, 2019 Peer-reviewed
MicroRNAs in extracellular vesicles: potential cancer biomarkers

Takashi Kinoshita, Kenneth W. Yip, Tara Spence, Fei-Fei Liu

JOURNAL OF HUMAN GENETICS, 62(1) 67-74, Jan, 2017 Peer-reviewed
Identification of tumor suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature

Fukumoto Ichiro, Kinoshita Takashi, Hanazawa Toyoyuki, Kikkawa Naoko, Chiyomaru Takeshi, Enokida Hideki, Yamamoto Noriko, Goto Yusuke, Nishikawa Rika, Nakagawa Masayuki …

CANCER RESEARCH, 75, Aug 1, 2015 Peer-reviewed
MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.

Fukumoto I, Hanazawa T, Kinoshita T, Kikkawa N, Koshizuka K, Goto Y, Nishikawa R, Chiyomaru T, Enokida H, Nakagawa M …

British journal of cancer, 112(5) 891-900, Mar, 2015
Tumor suppressive microRNAs (miR-29s/miR-218) regulate laminin-integrin signaling in head and neck squamous cell carcinoma

Kinoshita Takashi, Nohata Nijiro, Hanazawa Toyoyuki, Kikkawa Naoko, Yamamoto Noriko, Yoshino Hirofumi, Itesako Toshihiko, Enokida Hideki, Nakagawa Masayuki, Okamoto Yoshitaka …

CANCER RESEARCH, 74(19), Oct 1, 2014 Peer-reviewed
Genistein suppresses prostate cancer regulating long non-coding RNA

Chiyomaru Takeshi, Yamamura Soichiro, Fukuhara Shinichiro, Kinoshita Takashi, Majid Shahana, Saini Sharanjot, Chang Inik, Tanaka Yuichiro, Enokida Hideki, Seki Naohiko …

CANCER RESEARCH, 74(19), Oct 1, 2014 Peer-reviewed
The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer.

Yusuke Goto, Satoko Kojima, Rika Nishikawa, Hideki Enokida, Takeshi Chiyomaru, Takashi Kinoshita, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki

Oncotarget, 5(17) 7748-59, Sep 15, 2014 Peer-reviewed

Misc.

当科で経験した良性対称性脂肪腫症(Madelung病)の3症例

砂金美紀, 山崎一樹, 越塚慶一, 飯沼智久, 木下崇, 花澤豊行

日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集, 30th, 2020
当科における再発頭頸部癌に対するNivolumabの使用経験

越塚慶一, 花澤豊行, 砂金美紀, 木下崇, 飯沼智久, 山崎一樹, 米倉修二

日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集, 30th, 2020
miR-874によるp53依存的癌抑制機構の解析

橋本直子, 木下崇, 野畑二次郎, 中山哲俊, 鈴木穣, 菅野純夫, 松本雅記, 関直彦, 田中知明, 横手幸太郎

日本内分泌学会雑誌, 91(1) 305-305, Apr, 2015
頭頸部扁平上皮癌におけるマイクロRNAの関わり

木下崇

千葉医学雑誌, 91(1) 27-32, Feb, 2015
Elucidation of the cancer pathway in head and neck squamous cell carcinoma based on microRNA analysis

HANAZAWA Toyoyuki, KINOSHITA Takashi, SEKI Naohiko

jibi to rinsho, 61(1) S80-S86, 2015
癌転移モデルマウスを用いた癌転移抑制型マイクロRNAの抗腫瘍効果の解析

木下崇, 花澤豊行, 岡本美孝, 関直彦

千葉医学雑誌, 90(5) 189-190, Oct, 2014
Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma

Noriko Yamamoto, Takashi Kinoshita, Nijiro Nohata, Akira Mitsuhashi, Hirokazu Usui, Hirofumi Yoshino, Toshihiko Itesako, Hideki Enokida, Masayuki Nakagawa, Makio Shozu …

CANCER RESEARCH, 74(19), Oct, 2014
Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting LASP1 in prostate cancer

Rika Nishikawa, Yusuke Goto, Takashi Kinoshita, Shinichi Sakamoto, Takeshi Chiyomaru, Hideki Enokida, Satoko Kojima, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa …

CANCER RESEARCH, 74(19), Oct, 2014
マイクロRNA-143/145クラスターは前立腺癌において、GOLM1を標的とし、癌抑制遺伝子として機能する(microRNA-143/145 cluster functions as a tumor suppressor by targeting GOLM1 in prostate cancer)

小島聡子, 榎田英樹, 吉野裕史, 井出迫俊彦, 千代丸剛, 木下崇, 五島悠介, 布施美紀, 西川里佳, 納谷幸男 …

日本癌学会総会記事, 73回 P-1104, Sep, 2014
miR-874によるp53依存的アポトーシス誘導の分子機序の解明(miR-874 facilitates p53-dependent apoptosis, coordinately through activating p53 modification and repressing p21)

橋本直子, 木下崇, 野畑二次郎, 中山哲俊, 鈴木穣, 菅野純夫, 横手幸太郎, 関直彦, 田中知明

日本癌学会総会記事, 73回 P-2064, Sep, 2014
【鼻副鼻腔内視鏡手術Update】鼻副鼻腔良性腫瘍の内視鏡下手術

花澤豊行, 山崎一樹, 大木雄示, 飯沼智久, 木下崇, 岡本美孝

耳鼻咽喉科・頭頸部外科, 86(7) 529-532, Jun, 2014
前立腺癌マイクロRNA発現プロファイルの作成に基づく癌抑制型マイクロRNAが制御する分子ネットワークの探索

布施美樹, 小島聡子, 榎田英樹, 千代丸剛, 吉野裕史, 野畑二次郎, 木下崇, 坂本信一, 納谷幸男, 中川昌之 …

日本アンドロロジー学会総会記事, 33rd 42-43, May 9, 2014
当科における鼻副鼻腔悪性腫瘍に対する内視鏡下前頭蓋底手術について

花澤豊行, 山崎一樹, 吉川直子, 木下崇, 茶薗英明, 岡本美孝

頭頸部癌, 40(2) 184-184, May, 2014
下咽頭癌においてmiR-504はCDK6の制御を介して細胞増殖を抑制する

吉川直子, 木下崇, 福本一郎, 花澤豊行, 岡本美孝, 関直彦

頭頸部癌, 40(2) 189-189, May, 2014
下咽頭癌マイクロRNA発現プロファイルに基づく、癌抑制型マイクロRNAの探索と標的癌遺伝子の同定

木下崇, 福本一郎, 吉川直子, 花澤豊行, 岡本美孝, 関直彦

頭頸部癌, 40(2) 191-191, May, 2014
当科における耳下腺癌の術前診断最近10年間の検討

茶薗英明, 岡本美孝, 花澤豊行, 山崎一樹, 木下崇

頭頸部癌, 40(2) 203-203, May, 2014
THE FUNCTIONAL SIGNIFICANCE AND ITS REGULATED MOLECULAR TARGETS OF MICRORNA-23B/27B/24-1 CLUSTER IN PROSTATE CANCER

Yusuke Goto, Rika Nishikawa, Satoko Kojima, Shinichi Sakamoto, Koji Kawamura, Takashi Imamoto, Takeshi Chiyomaru, Hideki Enokida, Takashi Kinoshita, Yukio Naya …

JOURNAL OF UROLOGY, 191(4) E456-E457, Apr, 2014
TUMOR SUPPRESSIVE MICRORNA-224 INHIBITS CANCER CELL MIGRATION AND INVASION VIA TARGETING TPD52 IN PROSTATE CANCER

Yusuke Goto, Rika Nishikawa, Satoko Kojima, Shinichi Sakamoto, Koji Kawamura, Takashi Imamoto, Takeshi Chiyomaru, Hideki Enokida, Takashi Kinoshita, Yukio Naya …

JOURNAL OF UROLOGY, 191(4) E328-E328, Apr, 2014
miR-874によるp53依存的アポトーシス誘導の分子機序の解明

橋本直子, 木下崇, 野畑二次郎, 関直彦, 鈴木穣, 菅野純夫, 田中知明, 横手幸太郎

日本内分泌学会雑誌, 90(1) 285-285, Apr, 2014
下咽頭癌における癌抑制型microRNA-504の機能解析と標的分子の探索

吉川直子, 花澤豊行, 木下崇, 福本一郎, 岡本美孝

日本耳鼻咽喉科学会会報, 117(4) 528-528, Apr, 2014

Presentations

血液中エクソソームmicroRNA:がんバイオマーカーとしての現状と問題点

木下崇

第24回日本遺伝子診療学会大会, Jul 15, 2017 Invited

Research Projects

細胞外小胞を介した口腔扁平上皮癌細胞の悪性化能獲得機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

木下崇, 関直彦, 花澤豊行
Serum exosomal biomaker analysis in oral cacer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Kinoshita Takashi
Identification of microRNA-mediated networks in salivary duct carcinoma

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

KINOSHITA Takashi

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