論文

査読有り
2018年

Konjac ceramide (kCer) regulates NGF-induced neurite outgrowth via the sema3A signaling pathway

Journal of Oleo Science
  • Seigo Usuki
  • ,
  • Noriko Tamura
  • ,
  • Kohei Yuyama
  • ,
  • Tomohiro Tamura
  • ,
  • Katsuyuki Mukai
  • ,
  • Yasuyuki Igarashi

67
1
開始ページ
77
終了ページ
86
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.5650/jos.ess17141
出版者・発行元
Japan Oil Chemists Society

The tuber of the konjac plant is a source enriched with GlcCer (kGlcCer), and has been used as a dietary supplement to improve the dry skin and itching that are caused by a deficiency of epidermal ceramide. Previously, we showed chemoenzymatically prepared konjac ceramide has a neurite-outgrowth inhibitory effect that is very similar to that of Sema3A and is not seen with animal-type ceramides. While, it has been unclear whether kCer may act on Sema3A or TrkA signaling pathway. In the present study, we showed kCer induces phosphorylation of CRMP2 and microtubules depolymerization via Sema3A signaling pathway not TrkA. It is concluded that kCer may be a potential Sema3A-like agonist that activates Sema3A signaling pathway directly.

リンク情報
DOI
https://doi.org/10.5650/jos.ess17141
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29238028
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000419262500009&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-2409-6556
ID情報
  • DOI : 10.5650/jos.ess17141
  • ISSN : 1347-3352
  • ISSN : 1345-8957
  • ORCIDのPut Code : 45867870
  • PubMed ID : 29238028
  • SCOPUS ID : 85040039564
  • Web of Science ID : WOS:000419262500009

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