論文

査読有り
2014年

Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged nucleic acid on DNA binding affinity

CHEMICAL COMMUNICATIONS
  • Ajaya R. Shrestha
  • ,
  • Yutaro Kotobuki
  • ,
  • Yoshiyuki Hari
  • ,
  • Satoshi Obika

50
5
開始ページ
575
終了ページ
577
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/c3cc46017g
出版者・発行元
ROYAL SOC CHEMISTRY

A novel 2',4'-BNA/LNA analog bridged by guanidine, termed as guanidine bridged nucleic acid (GuNA), was synthesized and incorporated into oligonucleotides. Thermal stabilities and nuclease resistance of GuNA-modified oligonucleotides were investigated and compared with those of 2',4'-BNA/LNA and natural DNA oligonucleotides. GuNA exhibited interestingly high binding affinity towards complementary ssDNA than 2',4'-BNA/LNA.

Web of Science ® 被引用回数 : 21

リンク情報
DOI
https://doi.org/10.1039/c3cc46017g
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000328650000022&DestApp=WOS_CPL