論文

査読有り
2015年1月

Neurogenesis of the spiral ganglion cells in the cochlea requires the transcriptional cofactor TIS21

NEUROSCIENCE LETTERS
  • Takao Yamada
  • ,
  • Ryosei Minoda
  • ,
  • Toru Miwa
  • ,
  • Momoko Ise
  • ,
  • Hiroki Takeda
  • ,
  • Eiji Yumoto

584
開始ページ
265
終了ページ
269
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neulet.2014.10.001
出版者・発行元
ELSEVIER IRELAND LTD

The molecular mechanisms controlling the proliferation and differentiation of spiral ganglion cells (SGCs) in the inner ear are still largely unknown. TIS21 is a transcriptional cofactor that shows antiproliferative, antiapoptotic, and prodifferentiative effects on neural progenitor cells. To investigate the function of TIS21 during SGC development, we analyzed SGC neurogenesis from embryonic day 13.5 (E13.5) to postnatal day 4 (P4) in Tis21-GFP knock-in mice, in which the protein-encoding exon of the Tis21 gene was replaced by EGFP. Through E13.5 to P4, we found fewer SGCs in homozygous Tis21-GFP knock-in mice than in wildtype mice. Our results suggest that TIS21 is required for development of SGCs. Deleting Tis21 may affect progenitor cells or neuroblasts at the beginning of cochlear-vestibular ganglion formation and would consequently lead to a decrease in the number of SGCs. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1016/j.neulet.2014.10.001
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25451728
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000347579000050&DestApp=WOS_CPL

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