永田龍 (Ryu Nagata) - マイポータル

基本情報

所属: 大阪大学薬学研究科特任准教授

研究者番号: 20818489
ORCID iD: https://orcid.org/0000-0002-4870-9540
J-GLOBAL ID: 202401003795529408
researchmap会員ID: R000076187

論文

TRPC6-Mediated Zn2+ Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells.

Chenlin Su, Xinya Mi, Tomoya Ito, Yuri Kato, Akiyuki Nishimura, Ryu Nagata, Yasuo Mori, Motohiro Nishida

Biomolecules 15(2) 2025年2月12日
A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides

Hiroto Kohashi, Ryu Nagata, Yusuke Tamenori, Tomorrow Amatani, Yoshifumi Ueda, Yasuo Mori, Yuuya Kasahara, Satoshi Obika, Masahito Shimojo

Nucleic Acids Research 52(9) 4784-4798 2024年5月22日
Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression

Kazuhiro Nishiyama, Yuri Kato, Akiyuki Nishimura, Xinya Mi, Ryu Nagata, Yasuo Mori, Yasu Taka Azuma, Motohiro Nishida

International Journal of Molecular Sciences 25(4) 2024年2月
Myocardial TRPC6-mediated Zn²⁺ influx induces beneficial positive inotropy through β-adrenoceptors

Sayaka Oda, Kazuhiro Nishiyama, Yuka Furumoto, Yohei Yamaguchi, Akiyuki Nishimura, Xiaokang Tang, Yuri Kato, Takuro Numaga-Tomita, Toshiyuki Kaneko, Supachoke Mangmool …

Nature Communications 13(1) 2022年12月
Deletion of TRPC3 or TRPC6 fails to attenuate the formation of inflammation and fibrosis in non-alcoholic steatohepatitis

Kazuhiro Nishiyama, Chiemi Toyama, Yuri Kato, Tomohiro Tanaka, Akiyuki Nishimura, Ryu Nagata, Yasuo Mori, Motohiro Nishida

Biological and Pharmaceutical Bulletin 44(3) 431-436 2021年3月1日
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compoundss

Seishiro Sawamura, Masahiko Hatano, Yoshinori Takada, Kyosuke Hino, Tetsuya Kawamura, Jun Tanikawa, Hiroshi Nakagawa, Hideharu Hase, Akito Nakao, Mitsuru Hirano …

Molecular Pharmacology 89(3) 348-363 2016年3月
Effects of DSP-8658, a Novel Selective Peroxisome Proliferator-activated Receptors a/γ Modulator, on Adipogenesis and Glucose Metabolism in Diabetic Obese Mice

T. Goto, R. Nakayama, M. Yamanaka, M. Takata, T. Takazawa, K. Watanabe, K. Maruta, R. Nagata, J. Nagamine, A. Tsuchida …

Experimental and Clinical Endocrinology and Diabetes 123(8) 492-499 2015年5月26日
Development of novel activators for TRPC channels aiming to treatment of neurodegenerative disorders

Seishiro Sawamura, Masahiko Hatano, Yoshinori Takada, Takashi Kuwamura, Tomohiro Numata, Shigeki Kiyonaka, Kyosuke Hino, Tetsuya Kawamura, Jun Tanikawa, Hiroshi Nakagawa …

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 181P-181P 2014年査読有り
Structural insight into receptor-selectivity for lurasidone

Osamu Ichikawa, Kazuhiko Okazaki, Hiroyuki Nakahira, Megumi Maruyama, Ryu Nagata, Kumiko Tokuda, Tomoko Horisawa, Kazuto Yamazaki

Neurochemistry International 61(7) 1133-1143 2012年12月
Synthesis and pharmacological evaluation of novel benzoylazole-based PPAR α/γ activators

Kantaro Ushiroda, Katsunori Maruta, Takeshi Takazawa, Tomokazu Nagano, Mutsuo Taiji, Tetsuya Kohno, Yasuhiro Sato, Shinji Horai, Kazunori Yanagi, Ryu Nagata

Bioorganic and Medicinal Chemistry Letters 21(7) 1978-1982 2011年4月1日
Development of a new class of benzoylpyrrole-based PPARα/γ activators

Kantaro Ushiroda, Katsunori Maruta, Makoto Kitoh, Kiyotaka Iwai, Jun Nagamine, Atsushi Tsuchida, Mutsuo Taiji, Ryu Nagata

Bioorganic and Medicinal Chemistry Letters 21(1) 220-224 2011年1月1日
Combination therapy with SMP-534 and an angiotensin-converting enzyme inhibitor provides additional renoprotection in 5/6 nephrectomized rats

Tsuyoshi Tsujimura, Jun Nagamine, Eiji Sugaru, Michiko Ono-Kishino, Teruhisa Tokunaga, Makoto Kitoh, Ryu Nagata, Tsutomu Nakagawa, Mutsuo Taiji

Biological and Pharmaceutical Bulletin 32(12) 1991-1996 2009年12月
The anti-fibrotic agent SMP-534 attenuates bleomycin-induced pulmonary fibrosis in hamsters

Tsuyoshi Tsujimura, Michiko Ono-Kishino, Jun Nagamine, Eiji Sugaru, Teruhisa Tokunaga, Makoto Kitoh, Ryu Nagata, Tsutomu Nakagawa, Mutsuo Taiji

Biomedical Research 30(3) 177-182 2009年
Chronic administration of SMP-534 ameliorates renal dysfunction in 5/6 nephrectomized rats

Tsuyoshi Tsujimura, Jun Nagamine, Eiji Sugaru, Tsutomu Nakagawa, Michiko Ono-Kishino, Teruhisa Tokunaga, Makoto Kitoh, Ryu Nagata, Mutsuo Taiji

Nephron - Experimental Nephrology 110(4) 2008年12月
Amelioration of established diabetic nephropathy by combined treatment with SMP-534 (antifibrotic agent) and losartan in db/db mice

Eiji Sugaru, Tsutomu Nakagawa, Michiko Ono-Kishino, Jun Nagamine, Teruhisa Tokunaga, Makoto Kitoh, W. Ewan Hume, Ryu Nagata, Mutsuo Taiji

Nephron - Experimental Nephrology 105(2) 2007年1月
SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice

Eiji Sugaru, Tsutomu Nakagawa, Michiko Ono-Kishino, Jun Nagamine, Teruhisa Tokunaga, Makoto Kitoh, W. Ewan Hume, Ryu Nagata, Mutsuo Taiji

American Journal of Physiology - Renal Physiology 290(4) 2006年4月
Enhanced effect of combined treatment with SMP-534 (antifibrotic agent) and losartan in diabetic nephropathy

Eiji Sugaru, Tsutomu Nakagawa, Michiko Ono-Kishino, Jun Nagamine, Teruhisa Tokunaga, Makoto Kitoh, W. Ewan Hume, Ryu Nagata, Mutsuo Taiji

American Journal of Nephrology 26(1) 50-58 2006年4月
SMP-534 inhibits TGF-β-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis

Eiji Sugaru, Mutsuko Sakai, Kazuhiko Horigome, Teruhisa Tokunaga, Makoto Kitoh, W. Ewan Hume, Ryu Nagata, Tsutomu Nakagawa, Mutsuo Taiji

American Journal of Physiology - Renal Physiology 289(5 58-5) 2005年11月
Structure-activity relationships of the oxindole growth hormone secretagogues

Teruhisa Tokunaga, W. Ewan Hume, Jun Nagamine, Tetsuya Kawamura, Mutsuo Taiji, Ryu Nagata

Bioorganic and Medicinal Chemistry Letters 15(7) 1789-1792 2005年4月1日
Tricyclic indole-2-carboxylic acids: Highly in vivo active and selective antagonists for the glycine binding site of the NMDA receptor

Seiji Katayama, Nobuyuki Ae, Toru Kodo, Shuji Masumoto, Shinji Hourai, Chika Tamamura, Hiroyasu Tanaka, Ryu Nagata

Journal of Medicinal Chemistry 46(5) 691-701 2003年2月27日

もっとみる

MISC

Tricyclic quinoxalinediones, aza-kynurenic acids, and indole-2-carboxylic acids as in vivo active NMDA-glycine antagonists

Ryu Nagata, Seiji Katayama, Ken Ichi Ohtani, Hiroyasu Tanaka, Kozo Shimago

Current Topics in Medicinal Chemistry 6(7) 733-745 2006年4月
Synthesis and pharmacological profile of an orally-active growth hormone secretagogue, SM-130686

Jun Nagamine, Tetsuya Kawamura, Teruhisa Tokunaga, W. Ewan Hume, Ryu Nagata, Tsutomu Nakagawa, Mutsuo Taiji

Combinatorial Chemistry and High Throughput Screening 9(3) 187-196 2006年3月

共同研究・競争的資金等の研究課題

ピペラジン化合物類のTRPCチャネルに対する構造生物学的解析

日本学術振興会科学研究費助成事業基盤研究(C) 2025年4月 - 2028年3月

森誠之, 永田龍, 村田武士