2018年3月1日
Mouse models of psoriasis and their relevance
Journal of Dermatology
- ,
- 巻
- 45
- 号
- 3
- 開始ページ
- 252
- 終了ページ
- 263
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1111/1346-8138.14112
- 出版者・発行元
- Blackwell Publishing Ltd
Psoriasis is an inflammatory skin disorder that includes dynamic interactions between the immune system and skin and is clinically characterized by keratinocyte proliferation and distinct inflammatory cell infiltrates. Cross-talk between keratinocytes and immunocytes is essential for the development of psoriasis given that it mediates the production of cytokines, chemokines and growth factors. To resolve the pathogenesis of psoriasis, numerous experimental animal models have been generated. In this review, we discuss recent findings from mouse models, their relevancy to psoriasis and use, including the discovery of new therapies.
- ID情報
-
- DOI : 10.1111/1346-8138.14112
- ISSN : 1346-8138
- ISSN : 0385-2407
- PubMed ID : 29226571
- SCOPUS ID : 85042660855