論文

国際誌
2022年7月4日

Bone Remodeling in Mandible of Wistar Rats with Diabetes Mellitus and Osteoporosis.

European journal of dentistry
  • Nike Hendrijantini
  • ,
  • Yonatan Christian Suisan
  • ,
  • Rizko Wira Artha Megantara
  • ,
  • Bambang Agustono Satmoko Tumali
  • ,
  • Mefina Kuntjoro
  • ,
  • Muhammad Dimas Aditya Ari
  • ,
  • Ratri Maya Sitalaksmi
  • ,
  • Guang Hong

17
2
開始ページ
319
終了ページ
329
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1055/s-0042-1745768

OBJECTIVES:  This study aimed to determine some of bone molecular expressions and its possible bone remodeling pathway between diabetes mellitus (DM) and osteoporosis model in the mandibular bone of Wistar rats. MATERIALS AND METHODS:  Twenty-seven female Wistar rats were divided randomly into control and treatment groups. Treatment groups were injected with streptozotocin intraperitoneally to induce DM (P1) and underwent bilateral ovariectomy to generate osteoporosis (P2). All groups were terminated after 12 weeks. Immunohistochemical and hematoxylin-eosin staining were performed to determine the expression of Runt-related transcription factor 2 (RUNX2), Osterix, vascular endothelial growth factor (VEGF), receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and observed the osteoblast and osteoclast. Statistical analysis was performed using one-way analysis of variance. RESULTS:  The lowest mean of RUNX2 and VEGF expression was found in the P2 group. The lowest mean of Osterix expression was found in the P1 group. Both P1 and P2 groups of osteoblast/osteoclast ratio were decreased. There were no significant differences in the expression of TRAP between all groups; however, increased expression of RANKL/OPG ratio was only found in the P2 group. CONCLUSION:  DM and osteoporosis induce changes in the bone remodeling pathway which are represented by a decrease in osteoblast biomarkers and an increase in osteoclast biomarkers.

リンク情報
DOI
https://doi.org/10.1055/s-0042-1745768
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35785822
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85134540828&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85134540828&origin=inward
ID情報
  • DOI : 10.1055/s-0042-1745768
  • ISSN : 1305-7456
  • eISSN : 1305-7464
  • PubMed ID : 35785822
  • SCOPUS ID : 85134540828

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