2007年4月
GBV-B as a pleiotropic virus: distribution of GBV-B in extrahepatic tissues in vivo.
Microbes and infection
- 巻
- 9
- 号
- 4
- 開始ページ
- 515
- 終了ページ
- 21
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.micinf.2007.01.010
GB virus B (GBV-B) infection of New World monkeys is considered to be a useful surrogate model for hepatitis C virus (HCV) infection. GBV-B replicates in the liver and induces acute resolving hepatitis but little is known whether the other organs could be permissive for the virus. We investigated the viral tropism of GBV-B in tamarins in the acute stage of viral infection and found that the viral genomic RNA could be detected in a variety of tissues. Notably, a GBV-B-infected tamarin with marked acute viremia scarcely showed a sign of hepatitis, due to preferential infection in lymphoid tissues such as lymph nodes and spleen. These results indicate that GBV-B as well as HCV is a pleiotropic virus in vivo.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.micinf.2007.01.010
- ISSN : 1286-4579
- PubMed ID : 17349810