2012年2月
Diversity of MHC class I haplotypes in cynomolgus macaques
IMMUNOGENETICS
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- 巻
- 64
- 号
- 2
- 開始ページ
- 131
- 終了ページ
- 141
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00251-011-0568-y
- 出版者・発行元
- SPRINGER
Cynomolgus macaques are widely used as a primate model for human diseases associated with an immunological process. Because there are individual differences in immune responsiveness, which are controlled by the polymorphic nature of the major histocompatibility (MHC) locus, it is important to reveal the diversity of MHC in the model animal. In this study, we analyzed 26 cynomolgus macaques from five families for MHC class I genes. We identified 32 Mafa-A, 46 Mafa-B, 6 Mafa-I, and 3 Mafa-AG alleles in which 14, 20, 3, and 3 alleles were novel. There were 23 MHC class I haplotypes and each haplotype was composed of one to three Mafa-A alleles and one to five Mafa-B alleles. Family studies revealed that there were two haplotypes which contained two Mafa-A1 alleles. These observations demonstrated further the complexity of MHC class I locus in the Old World monkey.
- リンク情報
- ID情報
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- DOI : 10.1007/s00251-011-0568-y
- ISSN : 0093-7711
- J-Global ID : 201202210658627742
- Web of Science ID : WOS:000299079900006