論文

査読有り
2012年9月

Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates

IMMUNOGENETICS
  • Hitoshi Ohtani
  • ,
  • Taeko K. Naruse
  • ,
  • Yuki Iwasaki
  • ,
  • Hirofumi Akari
  • ,
  • Takafumi Ishida
  • ,
  • Tetsuro Matano
  • ,
  • Akinori Kimura

64
9
開始ページ
669
終了ページ
678
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00251-012-0628-y
出版者・発行元
SPRINGER

T-cell immunoglobulin domain and mucin domain containing protein 1 (TIM1), also known as a cellular receptor for hepatitis A virus (HAVCR1) or a molecule induced by ischemic injury in the kidney (KIM1), is involved in the regulation of immune responses. We investigated a natural selection history of TIM1 by comparative sequencing analysis in 24 different primates. It was found that TIM1 had become a pseudogene in multiple lineages of the New World monkey. We also investigated T cell lines originated from four different New World monkey species and confirmed that TIM1 was not expressed at the mRNA level. On the other hand, there were ten amino acid sites in the Ig domain of TIM1 in the other primates, which were suggested to be under positive natural selection. In addition, mucin domain of TIM1 was highly polymorphic in the Old World monkeys, which might be under balanced selection. These data suggested that TIM1 underwent a lineage-specific evolutionary pathway in the primates.

リンク情報
DOI
https://doi.org/10.1007/s00251-012-0628-y
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201202275234482803
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000307533900003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00251-012-0628-y
  • ISSN : 0093-7711
  • J-Global ID : 201202275234482803
  • Web of Science ID : WOS:000307533900003

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