2013年7月
Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration
IMMUNOLOGY LETTERS
- 巻
- 154
- 号
- 1-2
- 開始ページ
- 12
- 終了ページ
- 17
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.imlet.2013.08.005
- 出版者・発行元
- ELSEVIER SCIENCE BV
In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey, has been shown useful as an experimental animal model for various human diseases such as multiple sclerosis, Parkinson's disease and a number of infectious diseases. Here we show that an anti-marmoset CD8 mAb 6F10, which we have recently established, efficiently depletes the marmoset CD8+ T lymphocytes in vivo, i.e., the administration of 6F10 induces drastic and specific reduction in the ratio of the CD8(+) T cell subset for at least three weeks or longer. Our finding will help understand the pivotal role of CD8(+) T cells in vivo in the control of human diseases. (C) 2013 Elsevier B.V. All rights reserved.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.imlet.2013.08.005
- CiNii Articles
- http://ci.nii.ac.jp/naid/120005341875
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/23969290
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000326559400003&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1016/j.imlet.2013.08.005
- ISSN : 0165-2478
- eISSN : 1879-0542
- CiNii Articles ID : 120005341875
- PubMed ID : 23969290
- Web of Science ID : WOS:000326559400003