2016年2月
A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- 巻
- 80
- 号
- 2
- 開始ページ
- 313
- 終了ページ
- 317
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1080/09168451.2015.1083396
- 出版者・発行元
- TAYLOR & FRANCIS LTD
Myeloperoxidase (MPO)-generated halogenating molecules, such as hypochlorous acid and hypobromous acid (HOBr), in inflammatory regions are postulated to contribute to disease progression. In this study, we showed that ergothioneine (EGT), derived from an edible mushroom, inhibited MPO activity as well as the formation of 8-bromo-2-deoxyguanosine in vitro. The HOBr scavenging effect of EGT is higher than those of ascorbic acid and glutathione. We initially observed that the administration of Coprinus comatus, an edible mushroom containing a high amount of EGT, inhibited the UV-B-induced inflammatory responses and DNA halogenation, suggesting that EGT is a promising anti-inflammatory agent from mushrooms.
- リンク情報
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- DOI
- https://doi.org/10.1080/09168451.2015.1083396
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26338495
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000367835500014&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84956622229&origin=inward
- ID情報
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- DOI : 10.1080/09168451.2015.1083396
- ISSN : 0916-8451
- eISSN : 1347-6947
- PubMed ID : 26338495
- SCOPUS ID : 84956622229
- Web of Science ID : WOS:000367835500014