2014年11月
Tea Catechins Inhibit Cell Proliferation Through Hydrogen Peroxide-Dependent and -Independent Pathways in Human T lymphocytic Leukemia Jurkat Cells
FOOD SCIENCE AND TECHNOLOGY RESEARCH
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- 巻
- 20
- 号
- 6
- 開始ページ
- 1245
- 終了ページ
- 1249
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3136/fstr.20.1245
- 出版者・発行元
- KARGER
In the present study, we investigated the anti-proliferative effects of four tea catechins: (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg) and (-)-epigallocatechin gallate (EGCg) in human T lymphocytic leukemia Jurkat cells. Each catechin induced a significant cytotoxic effect on Jurkat cells. Combinations of EGCg with other catechins additively potentiated anti-proliferation, extracellular hydrogen peroxide formation, c-Jun N-terminal kinase (JNK) activation and interferon (IFN)-gamma mRNA expression. Catalase partly but significantly abolished the cytotoxicity induced by EGC or EGCg, whereas it did not influence the EC- or ECg-induced effect. Among the tea catechins, ECg synergistically enhanced the EGCg-induced JNK phosphorylation and IFN-gamma expression. The present findings provide evidence that tea catechins are able to concertedly induce cytotoxicity through the JNK/IFN-gamma pathway in both a hydrogen peroxide-dependent and -independent manner.
- リンク情報
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- DOI
- https://doi.org/10.3136/fstr.20.1245
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000346623200017&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84920988955&origin=inward
- ID情報
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- DOI : 10.3136/fstr.20.1245
- ISSN : 1344-6606
- SCOPUS ID : 84920988955
- Web of Science ID : WOS:000346623200017