2003年4月
Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: Differences between human and rat
FREE RADICAL BIOLOGY AND MEDICINE
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- 巻
- 34
- 号
- 7
- 開始ページ
- 840
- 終了ページ
- 849
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0891-5849(02)01434-X
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
(-)-Epicatechin is one of the most potent antioxidants present in the human diet. Particularly high levels are found in black tea, apples, and chocolate. High intake of catechins has been associated with reduced risk of cardiovascular diseases. There have been several reports concerning the bioavailability of catechins, however, the chemical structure of (-)-epicatechin metabolites in blood, tissues, and urine remains unclear. In the present study, we purified and elucidated the chemical structure of (-)-epicatechin metabolites in human and rat urine after oral administration. Three metabolites were purified from human urine including (-)-epicatechin-3'-O-glucuronide, 4'-O-methyl-(-)-epicatechin-3'-O-glucuronide, and 4'-O-methyl-(-)-epicatechin-5 or 7-O-glucuronide, according to H-1- and C-13-NMR, HMBC, and LC-MS analyses. The metabolites purified from rat urine were 3'-O-methyl-(-)-epicatechin, (-)-epicatechin-7-O-glucuronide, and 3'-O-methyl-(-)-epicatechin-7-O-glucuronide. These compounds were also detected in the blood of humans and rats by LC-MS. The presence of these metabolites in blood and urine suggests that catechins are metabolized and circulated in the body after administration of catechin-containing foods. (C) 2003 Elsevier Science Inc.
- リンク情報
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- DOI
- https://doi.org/10.1016/S0891-5849(02)01434-X
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/12654472
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000181735200007&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037376885&origin=inward
- ID情報
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- DOI : 10.1016/S0891-5849(02)01434-X
- ISSN : 0891-5849
- PubMed ID : 12654472
- SCOPUS ID : 0037376885
- Web of Science ID : WOS:000181735200007