論文

査読有り
2008年9月

Inhibitory effect of juniperonic acid (Delta-5c,11c,14c,17c-20 : 4, omega-3) on bombesin-induced proliferation of Swiss 3T3 cells

BIOLOGICAL & PHARMACEUTICAL BULLETIN
  • Jun-ichi Morishige
  • ,
  • Naoki Amano
  • ,
  • Kaoru Hirano
  • ,
  • Hiroaki Nishio
  • ,
  • Tamotsu Tanaka
  • ,
  • Kiyoshi Satouchi

31
9
開始ページ
1786
終了ページ
1789
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1248/bpb.31.1786
出版者・発行元
PHARMACEUTICAL SOC JAPAN

Juniperonic acid (Delta-5c,11c,14c,17c-20:4, JA) is a polymethylene-interrupted (PMI) fatty acid that occurs in Biota orientalis. In this study, we found that JA has an antiproliferative activity. Swiss 3T3 cells were preloaded with fatty acids before stimulation with bombesin, a mitogenic neuropeptide, and proliferation of the cells was assessed by [H-3]thymidine incorporation. Preloading of linoleic acid (Delta-9c,12c-18:2) significantly enhanced bombesin-induced proliferation. In contrast, preloading of eicosapentaenoic acid (Delta-5c,8c,11c,14c,17c-20:5, EPA) suppressed proliferation. Likewise, cells preloaded with JA showed I significantly curtailed response to bombesin. The antiproliferative potency of JA was equivalent to that of EPA. Sciadonic acid (Delta-5c,11c,14c-20:3), an omega-6 analogue of JA did not show antiproliferative activity, suggesting the importance of the omega-3 double bond rather than the PMI structure. The ERA-like activity of JA may be involved in the pharmaceutical activity of biota seeds, a psychoactive Chinese traditional medicine.

リンク情報
DOI
https://doi.org/10.1248/bpb.31.1786
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000259061700027&DestApp=WOS_CPL
ID情報
  • DOI : 10.1248/bpb.31.1786
  • ISSN : 0918-6158
  • Web of Science ID : WOS:000259061700027

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