Woojin KANG

Profile Information

Affiliation: Assistant Professor, Laboratory Animal Resource Center, University of Tsukuba

Degree: 博士（生物工学）(筑波大学)

J-GLOBAL ID: 201801001225423096
researchmap Member ID: B000302431

Research Interests

Research Areas

Research History

Nov, 2022 - Present

University of Tsukuba
Jul, 2022 - Oct, 2022

研究員, 長崎研究室, 筑波大学数理物質系物質工学域
Apr, 2016 - Jun, 2022

National Center for Child Health and Development
Apr, 2016 - Mar, 2021

National Center for Child Health and Development
Apr, 2015 - Mar, 2016

School of Agriculture, Department of Life Sciences, Meiji University
Apr, 2013 - Mar, 2015

Assistant Professor, University of Tsukuba
Apr, 2013 - Mar, 2015

Faculty of Life and Environmental Sciences, University of Tsukuba
Apr, 2012 - Mar, 2013

Graduate School of Life and Environmental Sciences, University of Tsukuba
Apr, 2010 - Mar, 2012

筑波大学日本学術振興会外国人特別研究員（JSPS）
Jun, 2002 - Feb, 2007

研究員, 免疫制御研究センター, 韓国蔚山大学

Education

Apr, 2007 - Mar, 2010

University of Tsukuba
Mar, 2000 - Feb, 2002

Animal Reproductive Physiology, College Natural Resources, Korea University
- Feb, 2000

Department of Animal Science, College of Natural Resources, Korea University

Awards

Jul, 2018

世界体外受精会議記念賞（基礎）, 新規クエン酸合成酵素eCSによる卵活性化メカニズム, 日本受精着床学会

康宇鎭, 原田裕一郎, 河野菜摘子, 齊藤英和, 宮戸健二
Jun, 2017

学術奨励賞, 精子形成過程におけるホスホリパーゼCzetaの新たな機能, 日本卵子学会

康宇鎭, 牧野麻亜子, 河野菜摘子, 宮戸真美, 齊藤英和, 宮戸健二

Papers

Embryonic β-Catenin Is Required for Priming of the Uterus to Implantation

Youki Takezawa, Maki Iwai, Yukiko Fujiki, Ryo Yokomizo, Harue Kishigami, Mami Miyado, Natsuko Kawano, Mitsutoshi Yamada, Miyuki Shindo, Miki Suzuki, Ban Sato, Daiki Katano, Shintaro Kamijo, Toshio Hamatani, Mamoru Tanaka, Akihiro Umezawa, Woojin Kang, Kenji Miyado

Laboratory Investigation, 100026-100026, Jan, 2023 Peer-reviewedCorresponding author
Efficient Superovulation and Egg Collection from Mice

Miyuki Shindo, Kenji Miyado, Woojin Kang, Maki Fukami, Mami Miyado

BIO-PROTOCOL, 12(11), Jun, 2022 Peer-reviewed
Trehalose Suppresses Lysosomal Anomalies in Supporting Cells of Oocytes and Maintains Female Fertility.

Woojin Kang, Eri Ishida, Mitsuyoshi Amita, Kuniko Tatsumi, Hitomi Yonezawa, Miku Yohtsu, Daiki Katano, Kae Onozawa, Erika Kaneko, Wakako Iwasaki, Natsuko Naito, Mitsutoshi Yamada, Natsuko Kawano, Mami Miyado, Ban Sato, Hidekazu Saito, Takakazu Saito, Kenji Miyado

Nutrients, 14(10), May 22, 2022 Peer-reviewedLead authorCorresponding author
Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis.

Yoshiki Hayashi, Soshiro Kashio, Kazutoshi Murotomi, Shinjiro Hino, Woojin Kang, Kenji Miyado, Mitsuyoshi Nakao, Masayuki Miura, Satoru Kobayashi, Masakazu Namihira

Scientific reports, 12(1) 5593-5593, Apr 4, 2022 Peer-reviewed
Cryopreservation of undifferentiated and differentiated human neuronal cells

Kenji Yamatoya, Yuya Nagai, Naozumi Teramoto, Woojin Kang, Kenji Miyado, Kazuya Nakata, Tohru Yagi, Yoshitaka Miyamoto

Regenerative Therapy, 19 58-68, Mar, 2022 Peer-reviewed
Suppressive Role of Lactoferrin in Overweight-Related Female Fertility Problems

Ban Sato, Seiya Kanai, Daiki Sakaguchi, Kodai Yajima, Yu Matsumoto, Kazunori Morohoshi, Shinji Kagaya, Nobuo Izumo, Minoru Ichinose, Woojin Kang, Mami Miyado, Kenji Miyado, Natsuko Kawano

Nutrients, 14(5) 938-938, Feb 22, 2022 Peer-reviewed
Extra-mitochondrial citrate synthase controls cAMP-dependent pathway during sperm acrosome reaction in mice.

Woojin Kang, Daiki Katano, Natsuko Kawano, Mami Miyado, Kenji Miyado

microPublication biology, 2022, 2022 Peer-reviewedLead authorCorresponding author
Emerging Role of TCA Cycle-Related Enzymes in Human Diseases

Woojin Kang, Miki Suzuki, Takako Saito, Kenji Miyado

International Journal of Molecular Sciences, 22(23) 13057-13057, Dec 2, 2021 Peer-reviewedLead authorCorresponding author
Identification of an antibacterial polypeptide in mouse seminal vesicle secretions

Kazunori Morohoshi, Takeo Yamazaki, Keiji Kito, Ban Sato, Woojin Kang, Taku Hibino, Manabu Yoshida, Kaoru Yoshida, Teruaki Iwamoto, Mitsutoshi Yamada, Kenji Miyado, Natsuko Kawano

Journal of Reproductive Immunology, 103436-103436, Oct, 2021 Peer-reviewed
Similar responsiveness between C57BL/6N and C57BL/6J mouse substrains to superovulation.

Miyuki Shindo, Hideki Tsumura, Kenji Miyado, Woojin Kang, Natsuko Kawano, Tomoko Yoshida, Maki Fukami, Mami Miyado

microPublication biology, Feb 25, 2021 Peer-reviewed
Next-Generation Sequencing Reveals Downregulation of the Wnt Signaling Pathway in Human Dysmature Cumulus Cells as a Hallmark for Evaluating Oocyte Quality

Ryosuke Akino, Daisuke Matsui, Ryouka Kawahara-Miki, Mitsuyoshi Amita, Kuniko Tatsumi, Eri Ishida, woojin Kang, Shuji Takada, Kenji Miyado, Akihiko Sekizawa, Takakazu Saito, Tomohiro Kono, Hidekazu Saito

Reproductive Medicine, 1(3) 205-215, Dec, 2020 Peer-reviewed
Suppression of Non-Random Fertilization by MHC Class I Antigens.

Junki Kamiya, Woojin Kang, Keiichi Yoshida, Ryota Takagi, Seiya Kanai, Maito Hanai, Akihiro Nakamura, Mitsutoshi Yamada, Yoshitaka Miyamoto, Mami Miyado, Yoko Kuroki, Yoshiki Hayashi, Akihiro Umezawa, Natsuko Kawano, Kenji Miyado

International journal of molecular sciences, 21(22), Nov 19, 2020 Peer-reviewedLead author
Neuronal expression of Ca2+ oscillation initiator is linked to rapid neonatal growth in mice.

Woojin Kang, Kenji Yamatoya, Kenji Miyado, Mami Miyado, Yoshitaka Miyamoto

microPublication biology, Nov 12, 2020 Peer-reviewedLead authorCorresponding author
Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female Reproductive Tract.

Daiki Sakaguchi, Kenji Miyado, Teruaki Iwamoto, Hiroshi Okada, Kaoru Yoshida, Woojin Kang, Miki Suzuki, Manabu Yoshida, Natsuko Kawano

International journal of molecular sciences, 21(11), May 31, 2020 Peer-reviewed
Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.

Woojin Kang, Yuichirou Harada, Kenji Yamatoya, Natsuko Kawano, Seiya Kanai, Yoshitaka Miyamoto, Akihiro Nakamura, Mami Miyado, Yoshiki Hayashi, Yoko Kuroki, Hidekazu Saito, Yasuhiro Iwao, Akihiro Umezawa, Kenji Miyado

Laboratory investigation; a journal of technical methods and pathology, 100(4) 583-595, Apr, 2020 Peer-reviewedLead author
Microexosomes versus exosomes: Shared components but distinct structures.

Mami Miyado, Woojin Kang, Natsuko Kawano, Kenji Miyado

Regenerative therapy, 11 31-33, Dec, 2019 Peer-reviewed
Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of SVS2 in Male Fertility.

Miyuki Shindo, Masafumi Inui, Woojin Kang, Moe Tamano, Cai Tingwei, Shuji Takada, Taku Hibino, Manabu Yoshida, Kaoru Yoshida, Hiroshi Okada, Teruaki Iwamoto, Kenji Miyado, Natsuko Kawano

International journal of molecular sciences, 20(18), Sep 14, 2019 Peer-reviewed
Chemotactic behavior of egg mitochondria in response to sperm fusion in mice.

Iwai M, Harada Y, Miyabayashi R, Kang W, Nakamura A, Kawano N, Miyamoto Y, Yamada M, Hamatani T, Miyado M, Yoshida K, Saito H, Tanaka M, Umezawa A, Miyado K

Heliyon, 4(11) e00944, Nov, 2018 Peer-reviewed
Membrane protein CD9 is repositioned and released to enhance uterine function.

Iwai M, Hamatani T, Nakamura A, Kawano N, Kanai S, Kang W, Yoshii N, Odawara Y, Yamada M, Miyamoto Y, Saito T, Saito H, Miyado M, Umezawa A, Miyado K, Tanaka M

Laboratory investigation; a journal of technical methods and pathology, 99(2) 200-209, Nov, 2018 Peer-reviewed
Degradation of phosphate polymer polyP enhances lactic fermentation in mice.

Nakamura A, Kawano N, Motomura K, Kuroda A, Sekiguchi K, Miyado M, Kang W, Miyamoto Y, Hanai M, Iwai M, Yamada M, Hamatani T, Saito T, Saito H, Tanaka M, Umezawa A, Miyado K

Genes Cells, 23(10) 904-914, Aug, 2018 Peer-reviewed

Misc.

Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction (vol 75, pg 847, 2019)

Woojin Kang, Yuichirou Harada, Kenji Yamatoya, Natsuko Kawano, Seiya Kanai, Yoshitaka Miyamoto, Akihiro Nakamura, Mami Miyado, Yoshiki Hayashi, Yoko Kuroki, Hidekazu Saito, Yasuhiro Iwao, Akihiro Umezawa, Kenji Miyado

LABORATORY INVESTIGATION, 100(4) 665-665, Apr, 2020
「生殖」から読み解く哺乳類の生命現象精漿タンパク質SVS2欠損マウスから見えてきた、精子を殺すメスの免疫機構

河野菜摘子, 康宇鎭, 吉田薫, 吉田学, 宮戸健二

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [3W20-p, Dec, 2015
Indoleamine 2,3-dioxygenase-expressing intestinal epithelial cells and plasmacytoid dendritic cells maintain oral tolerance

Kwang Hui Kim, Young H. Kim, Beom K. Choi, Sun K. Lee, Eun M. Choi, Chang H. Kim, Woo J. Kang, Kyung O. Nam, Su M. Shin, Sun H. Hwang, Sang W. Kang, Byoung S. Kwon

JOURNAL OF IMMUNOLOGY, 176 S183-S183, Apr, 2006
Effects of glucocorticoid-induced TNF receptor family-related gene signaling on CD4+ and CD8+ T cells in a mouse colitis model

Sun K. Lee, Beom K. Choi, Young H. Kim, Woo J. Kang, Kwang H. Kim, Tae Y. Kim, Byoung S. Kwon

JOURNAL OF IMMUNOLOGY, 176 S180-S180, Apr, 2006
Generation of suppressor CD8+T cells by triggering 4-1BB

Beorn K. Choi, Woo J. Kang, Young H. Kim, Byoung S. Kwon

JOURNAL OF IMMUNOLOGY, 176 S186-S186, Apr, 2006
4-1BB-mediated immunotherapy of rheumatoid (vol 10, pg 1088, 2004)

SK Seo, JH Choi, YH Kim, WJ Kang, HY Park, JH Suh, BK Choi, DS Vinay, BS Kwon

NATURE MEDICINE, 10(11) 1261-1261, Nov, 2004

Books and Other Publications

Reproductive and Developmental Strategies

Miyado K, Yamatoya K, Kang W, Kawano N (Role: Joint author, Regulation of Sperm-Egg Fusion at the Plasma Membrane)

2018

Presentations

毛色によって男性の生殖能は判別できるのか？

The 42nd Annual Meeting of the Molecular Biology Society of Japan, Dec 4, 2019
新規クエン酸合成酵素eCSによる卵活性化メカニズム

康宇鎭, 原田裕一郎, 河野菜摘子, 齊藤英和, 宮戸健二

日本生殖医学会雑誌, Aug, 2018
顆粒膜細胞の細胞死を制御する2つの分子メカニズム

康宇鎭, 石田恵理, 大和屋健二, 巽国子, 要津みく, 米澤瞳, 齊藤隆和, 宮戸健二, 齊藤英和

日本卵子学会誌, Apr, 2018
生殖工学と生殖医学の融合~育種から不妊診断・治療への展開~

宮戸健二, 花井慎弦, KANG Woojin, 中村彰宏, 河野菜摘子

日本生物工学会大会講演要旨集, Aug, 2017
卵障害性物質の探索と対処法の開発―受精の基礎研究からのアプローチ―

宮戸健二, 康宇鎭, 齊藤英和, 宮戸真美, 河野菜摘子

Apr, 2017
精子形成過程におけるホスホリパーゼCzetaの新たな機能

康宇鎭, 牧野麻亜子, 河野菜摘子, 宮戸真美, 齊藤英和, 宮戸健二

日本卵子学会誌, Apr, 2017
精漿タンパク質SVS2欠損マウスから見えてきた,精子を殺すメスの免疫機構

河野菜摘子, 康宇鎭, 吉田薫, 吉田学, 宮戸健二

日本生化学会大会(Web), 2015
Acrosome reaction of mouse epididymal sperm facilitates the entry into the cumulus mass

Woojin Kang, Tadashi Baba

Fertilization and Activation of Development Gordon Research Conference, Jul 19, 2011 Invited
Functional Roles of Sperm Hyaluronidases, HYAL5 and SPAM1, in Mouse Fertilization

Woojin Kang, Masanori Kimura, Ekyune Kim, Taiga Yamazaki, Misuzu Yamashita, Mariko Saigo, Shin-ichi Kashiwabara, Tadashi Baba

BIOLOGY OF REPRODUCTION, 2009, SOC STUDY REPRODUCTION
Male mice lacking both acrosin and Prss21/Tesp5 are subfertile

Natsuko Kawano, Misuzu Yamashita, Woo-Jin Kang, Shia-ichi Kashiwabara, Tadashi Baba

BIOLOGY OF REPRODUCTION, 2008, SOC STUDY REPRODUCTION

Professional Memberships

Research Projects

栄養摂取・代謝サイクルの加齢にともなう細胞から器官レベルでの転換

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2026

康宇鎮, 宮戸真美, 河野菜摘子
Dysmature卵子解析を用いた難治性不妊症患者のART治療成績向上への挑戦

科学研究費補助金基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

網田光善, 斉藤隆和, 石田恵理, 巽国子, 康宇鎭, 宮戸健二
加齢による妊孕性低下とそれを防ぐ分子メカニズムの解明

科学研究費補助金基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

康宇鎭, 河野菜摘子, 宮戸健二
受精過程での精子と卵子卵丘細胞複合体の相互作用

科学研究費助成事業特別研究員奨励費, 日本学術振興会, 2010 - 2011

馬場忠, 康宇鎭

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