2022年
Extra-mitochondrial citrate synthase controls cAMP-dependent pathway during sperm acrosome reaction in mice.
microPublication biology
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- 巻
- 2022
- 号
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.17912/micropub.biology.000579
The sperm consumes adenosine triphosphate (ATP) to maintain the cellular function, viability, acrosome reaction (AR), and motility. Extra-mitochondrial citrate synthase (eCS) catalyzes citrate production in the sperm head, and thus regulates sperm function through ATP synthesis, similarly to CS. This study aimed to investigate how eCS regulates AR. Herein, acrosome-reacted (ARed) sperms were rarely detected on the zona pellucida, and spontaneous ARed sperm in eCs -deficient (KO) sperm remained at low levels even with induced capacitation. Retarded AR of eCs -KO sperm was enhanced by cyclic adenosine 3',5'-monophosphate (cAMP) treatment. In conclusion, eCS regulates AR via a cAMP-dependent pathway, which presumably contributes to sperm metabolism.
- リンク情報
- ID情報
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- DOI : 10.17912/micropub.biology.000579
- PubMed ID : 35663411
- PubMed Central 記事ID : PMC9160978