2019年3月
Application of transcutaneous carbon dioxide improves capillary regression of skeletal muscle in hyperglycemia.
The journal of physiological sciences : JPS
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- 巻
- 69
- 号
- 2
- 開始ページ
- 317
- 終了ページ
- 326
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12576-018-0648-y
The purpose of the present study was to determine the effects of transcutaneous CO2 application on the blood flow and capillary architecture of the soleus muscle in rats with streptozotocin (STZ)-induced hyperglycemia. Wistar rats were randomly divided into four groups: control, control + CO2-treated, STZ-induced hyperglycemia, and STZ-induced hyperglycemia + CO2-treated groups. Blood flow in soleus muscle increased during the transcutaneous CO2 exposure, and continued to increase for 30 min after the treatment. In addition, the transcutaneous CO2 attenuated a decrease in capillary and the expression level of eNOS and VEGF protein, and an increase in the expression level of MDM-2 and TSP-1 protein of soleus muscle due to STZ-induced hyperglycemia. These results indicate that the application of transcutaneous CO2 could improve capillary regression via the change of pro- and anti-angiogenesis factors, which might be induced by an increase in blood flow.
- リンク情報
- ID情報
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- DOI : 10.1007/s12576-018-0648-y
- ISSN : 1880-6546
- PubMed ID : 30478742