2014年
Radiation-induced undifferentiated high-grade pleomorphic sarcoma (malignant fibrous histiocytoma) of the mandible: Report of a case arising in the background of long-standing osteomyelitis with a review of the literature
PATHOLOGY RESEARCH AND PRACTICE
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- 巻
- 210
- 号
- 12
- 開始ページ
- 1123
- 終了ページ
- 1129
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.prp.2014.06.028
- 出版者・発行元
- ELSEVIER GMBH, URBAN & FISCHER VERLAG
We report a rare case of radiation-induced undifferentiated high-grade pleomorphic sarcoma (UPS) (malignant fibrous histiocytoma, MFH) in the right mandible of a 44-year-old woman. The patient had suffered from osteomyelitis of the same region of the mandible for several years, which was considered to be due to radiotherapy for a malignant lymphoma in her right neck 19 years before. The tumor appeared as an exophytic and invasive growth in the molar region of the mandible. Histopathologically, the tumor consisted of an interlacing proliferation of vimentin-immunopositive spindle-shaped fibroblastic cells with bizarre nuclei with high Ki-67 labeling scores, and tumor cells showed storiform patterns mixed with pleomorphic cells. Taking the history of radiation into consideration, we diagnosed the lesion as radiation-induced MFH/UPS. Including the present case, there have been only 14 documented cases of radiation-induced UPS in the jawbone, and this is the first UPS case arising in the follow-up period of long-standing osteomyelitis. (C) 2014 Elsevier GmbH. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.prp.2014.06.028
- ISSN : 0344-0338
- PubMed ID : 25086676
- Web of Science ID : WOS:000346454200055