論文

査読有り
2011年

Enhanced Expression of Podoplanin in Oral Carcinomas in situ and Squamous Cell Carcinomas

PATHOBIOLOGY
  • Akinori Funayama
  • ,
  • Jun Cheng
  • ,
  • Satoshi Maruyama
  • ,
  • Manabu Yamazaki
  • ,
  • Takanori Kobayashi
  • ,
  • Mei Syafriadi
  • ,
  • Sukalyan Kundu
  • ,
  • Susumu Shingaki
  • ,
  • Chikara Saito
  • ,
  • Takashi Saku

78
3
開始ページ
171
終了ページ
180
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1159/000324926
出版者・発行元
KARGER

Objective: Podoplanin, a known lymphatic endothelial cell marker, has been reported to be expressed in various types of cancer. To elucidate the expression of podoplanin in precancerous lesions, we examined the immunohistochemical profiles of podoplanin in oral squamous epithelial lesions. Method: We studied a total of 298 foci of squamous cell carcinoma (SCC), carcinoma in situ (CIS), epithelial dysplasia, and hyperplastic and/or normal epithelial lesions by immunohistochemistry using D2-40. Results: There was no positivity for podoplanin in normal or hyperplastic epithelia, while all of the CIS and SCC foci stained positive. Approximately one third of the mild dysplasia foci (10 of 36 foci, 28%) and 80% of moderate dysplasia foci (78/98) showed grade 1 positive reactions (positive only in the 1st layer). Grade 2 reactions (up to 4th layer) were seen in 4 of 98 moderate dysplasia foci (4%), 29 of 74 CIS foci (39%), and 3 of 30 SCC foci (10%). Grade 3 reactions (to more than 5th layer) were found in 35 (47%) CIS foci and 26 (87%) SCC foci. Conclusions: The relationship between the present histological categorization and podoplanin grade was statistically significant. D2-40 expression is considered to be related to the severity of oral precancerous lesions. Copyright (C) 2011 S. Karger AG, Basel


リンク情報
DOI
https://doi.org/10.1159/000324926
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21613804
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000292410900006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1159/000324926
  • ISSN : 1015-2008
  • PubMed ID : 21613804
  • Web of Science ID : WOS:000292410900006

エクスポート
BibTeX RIS