論文

査読有り
2010年12月

Combined immunohistochemistry for the differential diagnosis of cystic jaw lesions: its practical use in surgical pathology

HISTOPATHOLOGY
  • Masayuki Tsuneki
  • ,
  • Manabu Yamazaki
  • ,
  • Jun Cheng
  • ,
  • Satoshi Maruyama
  • ,
  • Takanori Kobayashi
  • ,
  • Takashi Saku

57
6
開始ページ
806
終了ページ
813
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1365-2559.2010.03712.x
出版者・発行元
WILEY-BLACKWELL PUBLISHING, INC

Combined immunohistochemistry for the differential diagnosis of cystic jaw lesions: its practical use in surgical pathology
Aims:
Histopathological distinction of cystic jaw lesions, including odontogenic tumours, is challenging because their lining epithelia, which are basically stratified squamous epithelia, resemble each other, especially when they become hyperplastic from inflammatory reaction. The aim of this study was to seek practical measures to differentiate such lesions.
Methods and results:
Nineteen surgical specimens from unicystic ameloblastomas (UAs), 17 from keratocystic odontogenic tumours (KCOTs), 13 from dentigerous cysts (DCs), 10 from lateral periodontal cysts (LPCs) and 20 from radicular cysts (RCs), all of which contained both typical flat and rete-peg-shaped lining epithelia, were examined for their immunohistochemical profiles. Among them, keratin (K) 10, K17, perlecan, proliferating cell nuclear antigen (PCNA) and UEA-I lectin binding (UEA) were selected as useful immunohistochemical markers for their differential diagnosis. K10 was positive (+) in KCOT and DC. K17 was not present in RC. Perlecan was found in UA, KCOT and LPC. PCNA+ cells were found frequently in UA and KCOT. These localization patterns were constant even when linings were not flat.
Conclusions:
Using a combination of six kinds of immunohistochemical pattern, it is now possible to discriminate reliably and objectively these five cystic jaw lesions in routine practice.


リンク情報
DOI
https://doi.org/10.1111/j.1365-2559.2010.03712.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21166695
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000285417800004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1365-2559.2010.03712.x
  • ISSN : 0309-0167
  • PubMed ID : 21166695
  • Web of Science ID : WOS:000285417800004

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