論文

査読有り
2009年10月

Oral solitary fibrous tumor: a cytogenetic analysis of tumor cells in culture with literature review

CANCER GENETICS AND CYTOGENETICS
  • Wael M. Swelam
  • ,
  • Jun Cheng
  • ,
  • Hiroko Ida-Yonemochi
  • ,
  • Satoshi Maruyama
  • ,
  • Takashi Saku

194
2
開始ページ
75
終了ページ
81
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cancergencyto.2009.05.003
出版者・発行元
ELSEVIER SCIENCE INC

Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm of mesenchymal origin. Because the pathogenetic background of SFT is still controversial, cytogenetic analysis could help in tumor diagnosis and prognosis. In this study, cultured SFT cells from a lower lip lesion that presented characteristic immunopositivity for CD34, vimentin, CD99, and BCL2 showed a unique cytogenetic finding: 46,XX,inv(2)(p21q35),t(3;12)(q25;q15). To our knowledge, this is the third report of cytogenetic result of a case involving the oral cavity. The SFT cells in culture that maintained their immunohistochemical expression of diagnostic molecules, showed unique chromosomal changes previously unreported when compared with already documented ones. Our data suggest that the complicated pathogenetic nature of SFT is possibly tumor- or organ-related. (C) 2009 Elsevier Inc. All rights reserved.


リンク情報
DOI
https://doi.org/10.1016/j.cancergencyto.2009.05.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19781439
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000270585200002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.cancergencyto.2009.05.003
  • ISSN : 0165-4608
  • PubMed ID : 19781439
  • Web of Science ID : WOS:000270585200002

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