論文

査読有り
2008年5月

Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor

JOURNAL OF ORAL PATHOLOGY & MEDICINE
  • Masayuki Tsuneki
  • ,
  • Jun Cheng
  • ,
  • Satoshi Maruyama
  • ,
  • Hiroko Ida-Yonemochi
  • ,
  • Motowo Nakajima
  • ,
  • Takashi Saku

37
5
開始ページ
287
終了ページ
293
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1600-0714.2007.00620.x
出版者・発行元
BLACKWELL PUBLISHING

BACKGROUND: The intraepithelial deposit of perlecan, a basement membrane-type heparan sulfate (HS) proteoglycan, has been demonstrated in neoplastic conditions such as salivary gland tumors, odontogenic tumors, and oral carcinoma in situ. Our aim was to determine whether perlecan turnover was enhanced in the lining cells of keratocystic odontogenic tumor (KCOT), which had been recently renamed from odontogenic keratocyst because of its accumulated evidence of neoplasm, as a possible background for neoplastic proliferation.
METHODS: Ten surgical specimens from each of KCOT, dentigerous cyst, and radicular cyst were examined for the expressions of perlecan core protein, HS chains, heparanase, and Ki-67 by immunohistochemistry and in situ hybridization.
RESULTS: In KCOT, perlecan core protein and HS chains were localized on the cell border from the parabasal to subkeratinized layers of the lining epithelium. Heparanase was localized in a similar fashion to those for perlecan and HS chains but was within the cytoplasm. mRNA signals for perlecan core protein and heparanase were mostly compatible with their protein signals. Ki-67-positive cells were localized mainly in the second basal cell layers with definitely higher labeling indices (approximately 31.3%, second layer). In contrast to KCOT, dentigerous cysts and radicular cysts had no perlecan, HS chains, and heparanase deposition in their linings with extremely lower Ki-67 indices (0.4-0.8%).
CONCLUSION: The result suggests that the characteristic intra-lining-epithelial deposit of perlecan in KCOT, which has never been seen in other cystic jaw lesions, is a new evidence supporting the neoplastic nature of KCOT.


リンク情報
DOI
https://doi.org/10.1111/j.1600-0714.2007.00620.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18205742
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000254953400004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1600-0714.2007.00620.x
  • ISSN : 0904-2512
  • PubMed ID : 18205742
  • Web of Science ID : WOS:000254953400004

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