論文

国際誌
2021年6月7日

Other iatrogenic immunodeficiency-associated lymphoproliferative disorders in the oral cavity: a clinicopathologic study of 4 cases and literature review.

Oral surgery, oral medicine, oral pathology and oral radiology
  • Masami Kawaharada
  • ,
  • Satoshi Maruyama
  • ,
  • Tatsuya Abé
  • ,
  • Manabu Yamazaki
  • ,
  • Akira Kurokawa
  • ,
  • Wataru Katagiri
  • ,
  • Ritsuo Takagi
  • ,
  • Takafumi Hayashi
  • ,
  • Tadaharu Kobayashi
  • ,
  • Jun-Ichi Tanuma

132
6
開始ページ
687
終了ページ
697
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.oooo.2021.05.015

OBJECTIVES: Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OI-LPD) have been reported as one of the adverse effects of immunosuppressive therapy. The aim of this study was to describe the clinicopathologic and immunohistochemical features of OI-LPD in the oral cavity. STUDY DESIGN: Immunohistochemistry was performed to describe the immunohistochemical features in our 4 cases. The results were analyzed along with 62 cases of oral OI-LPD in the English and Japanese literature to define clinical and pathologic characteristic features. RESULTS: In our immunohistochemical analysis, Epstein-Barr virus (EBV)-positive OI-LPD showed a higher percentage of mouse double minute 2-positive cells than EBV-negative samples. A literature survey revealed that OI-LPD (including the present cases) arises primarily in the gingiva, followed by the tongue, and usually occurs with a male-to-female ratio of 1:1.9. The rate of EBV positivity was 93.8%. Further, 31 of 66 patients had osteonecrosis of the jaw and 24 of 31 patients had taken multiple immunosuppressive drugs in combination. CONCLUSIONS: We can therefore conclude that the overexpression of mouse double minute 2 in OI-LPD is associated with EBV infection, and the combination of multiple immunosuppressive drugs may be a risk factor for osteonecrosis of the jaw.

リンク情報
DOI
https://doi.org/10.1016/j.oooo.2021.05.015
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34511340
ID情報
  • DOI : 10.1016/j.oooo.2021.05.015
  • PubMed ID : 34511340

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