論文

査読有り
2003年12月

Ultrastructure of ceramic-bone interface using hydroxyapatite and beta-tricalcium phosphate ceramics and replacement mechanism of beta-tricalcium phosphate in bone

TISSUE & CELL
  • R Fujita
  • ,
  • A Yokoyama
  • ,
  • Y Nodasaka
  • ,
  • T Kohgo
  • ,
  • T Kawasaki

35
6
開始ページ
427
終了ページ
440
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0040-8166(03)00067-3
出版者・発行元
CHURCHILL LIVINGSTONE

Hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) are useful for grafting and augmentation of bone tissue. Observation by transmission electron microscopy (TEM) was done to investigate the ultrastructures at the interfaces between the biomaterials and the adjacent tissue, and osteogenesis around the biomaterials in the present study. HA and beta-TCP ceramics were used in disk forms which had macropores and micropores, and were implanted between the parietal bone and the cranial periosteum of rats. Specimens were prepared for observation at 4 and 8 weeks postoperatively.
The microscopic results indicated that an intervening layer was present on the surface of HA, whereas it was not present on the surface of beta-TCP. A characteristic fibrillar structure was observed in the intervening layer between HA and bone under decalcification by HCl. In beta-TCP, in reticular structures observed close to the bone tissue by optical microscopy, calcification and sparse collagen fibers were interspersed among the granules of beta-TCP. In addition, close to the interface between beta-TCP and bone, many osteocytes with numerous processes were present. Some processes were elongated towards the inter-face.
These results revealed the difference in the ultrastructures of the inter-faces between HA and beta-TCP, and the dissolution mechanism of beta-TCP in bone. (C) 2003 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 41

リンク情報
DOI
https://doi.org/10.1016/S0040-8166(03)00067-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/14580356
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000186595600002&DestApp=WOS_CPL

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