柴徳生 (Norio Shiba) - マイポータル

基本情報

学位: 博士（医学）(群馬大学)

J-GLOBAL ID: 201601007667765690
researchmap会員ID: 7000016201

小児急性骨髄性白血病（AML)の治療成績向上を目指して、遺伝子解析、機能解析を行っています。

研究キーワード

研究分野

ライフサイエンス / 胎児医学、小児成育学 /

受賞

2020年11月

第10回日本小児血液・がん学会学術賞, 日本小児血液・がん学会

柴徳生
2017年11月

学術賞（臨床）, High PRDM16 expression identifies a prognostic subgroup of pediatric AML, 日本小児血液がん学会

柴徳生
2013年10月

2014年日本血液学会研究奨励賞, 日本血液学会

柴徳生

主要な論文

0

Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia

Genki Yamato, Tomoko Kawai, Norio Shiba, Junji Ikeda, Yusuke Hara, Kentaro Ohki, Shin-Ichi Tsujimoto, Taeko Kaburagi, Kenichi Yoshida, Yuichi Shiraishi …

Blood Advances 6(11) 3207-3219 2022年6月14日査読有り
0

Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia.

Taeko Kaburagi, Genki Yamato, Norio Shiba, Kenichi Yoshida, Yusuke Hara, Ken Tabuchi, Yuichi Shiraishi, Kentaro Ohki, Manabu Sotomatsu, Hirokazu Arakawa …

Haematologica 107(3) 583-592 2022年3月1日査読有り
Droplet digital polymerase chain reaction assay for the detection of the minor clone of KIT D816V in paediatric acute myeloid leukaemia especially showing RUNX1‐RUNX1T1 transcripts

Koji Sasaki, Shinichi Tsujimoto, Mayuko Miyake, Yuri Uchiyama, Junji Ikeda, Masahiro Yoshitomi, Yuko Shimosato, Mayu Tokumasu, Hidemasa Matsuo, Kenichi Yoshida …

British Journal of Haematology 194(2) 414-422 2021年7月査読有り
0

Patients aged less than 3 years with acute myeloid leukaemia characterize a molecularly and clinically distinct subgroup.

Yusuke Hara, Norio Shiba, Genki Yamato, Kentaro Ohki, Ken Tabuchi, Manabu Sotomatsu, Daisuke Tomizawa, Akitoshi Kinoshita, Hirokazu Arakawa, Akiko M Saito …

British journal of haematology 188(4) 528-539 2020年2月査読有り
46

Negative CD19 expression is associated with inferior relapse-free survival in children with RUNX1-RUNX1T1-positive acute myeloid leukaemia: results from the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study.

Sakamoto K, Shiba N, Deguchi T, Kiyokawa N, Hashii Y, Moriya-Saito A, Tomizawa D, Taga T, Adachi S, Horibe K …

British journal of haematology 187(3) 372-376 2019年11月査読有り
0

Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.

Shiba N, Yoshida K, Hara Y, Yamato G, Shiraishi Y, Matsuo H, Okuno Y, Chiba K, Tanaka H, Kaburagi T …

Blood advances 3(20) 3157-3169 2019年10月査読有り
0

Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study.

Miyamura T, Moritake H, Nakayama H, Tanaka S, Tomizawa D, Shiba N, Saito AM, Tawa A, Shimada A, Iwamoto S …

British journal of haematology 185(2) 284-288 2019年4月査読有り
0

Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia.

Hidemasa Matsuo, Kenichi Yoshida, Kazutaka Fukumura, Kana Nakatani, Yuki Noguchi, Saho Takasaki, Mina Noura, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba …

Blood advances 2(21) 2879-2889 2018年11月13日査読有り
0

Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study.

Akira Shimada, Yuka Iijima-Yamashita, Akio Tawa, Daisuke Tomizawa, Miho Yamada, Shiba Norio, Tomoyuki Watanabe, Takashi Taga, Shotaro Iwamoto, Kiminori Terui …

International journal of hematology 107(5) 586-595 2018年5月査読有り
0

RUNX1 mutations in pediatric acute myeloid leukemia are associated with distinct genetic features and an inferior prognosis.

Yamato G, Shiba N, Yoshida K, Hara Y, Shiraishi Y, Ohki K, Okubo J, Park MJ, Sotomatsu M, Arakawa H …

Blood. 131(20) 2266-2270 2018年4月査読有り
0

Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia

Genki Yamato, Hiroki Yamaguchi, Hiroshi Handa, Norio Shiba, Machiko Kawamura, Satoshi Wakita, Koiti Inokuchi, Yusuke Hara, Kentaro Ohki, Jun Okubo …

GENES CHROMOSOMES & CANCER 56(11) 800-809 2017年11月査読有り
0

Outcome of relapsed core binding factor acute myeloid leukemia in children: A result from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05R study

Hiroshi Moritake, Shiro Tanaka, Hideki Nakayama, Takako Miyamura, Shotaro Iwamoto, Akira Shimada, Kiminori Terui, Akiko Saito, Norio Shiba, Yasuhide Hayashi …

Pediatric Blood & Cancer 64(10) e26491-e26491 2017年10月査読有り
0

Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia

Norio Shiba, Kenichi Yoshida, Yuichi Shiraishi, Yusuke Okuno, Genki Yamato, Yusuke Hara, Yasunobu Nagata, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui …

BRITISH JOURNAL OF HAEMATOLOGY 175(3) 476-489 2016年11月査読有り筆頭著者
0

High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3-ITD, KMT2A-PTD, and NUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial

Norio Shiba, Kentaro Ohki, Tohru Kobayashi, Yusuke Hara, Genki Yamato, Reo Tanoshima, Hitoshi Ichikawa, Daisuke Tomizawa, Myoung-ja Park, Akira Shimada …

BRITISH JOURNAL OF HAEMATOLOGY 172(4) 581-591 2016年2月査読有り筆頭著者
0

NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia.

Norio Shiba, Hitoshi Ichikawa, Tomohiko Taki, Myoung-Ja Park, Aoi Jo, Sachiyo Mitani, Tohru Kobayashi, Akira Shimada, Manabu Sotomatsu, Hirokazu Arakawa …

Genes, chromosomes & cancer 52(7) 683-93 2013年7月査読有り筆頭著者