2017年
High prevalence of vitamin B-12 insufficiency in patients with Crohn's disease
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
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- 巻
- 26
- 号
- 6
- 開始ページ
- 1076
- 終了ページ
- 1081
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.6133/apjcn.022017.13
- 出版者・発行元
- H E C PRESS, HEALTHY EATING CLUB PTY LTD
Background and Objectives: In Crohn's disease (CD), belonging to inflammatory bowel disease, the small intestine is involved in most cases. Most frequently affected is the distal ileum, where vitamin B-12 is specifically absorbed. Therefore, malabsorption of vitamin B-12 is quite likely to occur in patients with CD. In this study, we have studied the vitamin B-12 status in CD patients. Methods and Study Design: Forty eight patients with CD were evaluated for their food intake, and circulating concentrations of vitamin B-12, folic acid, and homocysteine (Hcy) as a sensitive marker for the insufficiency of these vitamins and a risk factor of atherosclerosis. Results: Plasma Hcy concentration was significantly correlated with serum vitamin B-12 concentration alone, and 60.4 % of the subjects had hyperhomocysteinemia. Receiver Operating Characteristics (ROC) analysis showed that serum concentration of vitamin B-12, but not folic acid, predicted hyperhomocysteinemia. Their intake of vitamin B-12 was much higher than the Japanese RDA, but not correlated with blood concentrations of vitamin B-12 or Hcy, probably due to malabsorption. Conclusions: Vitamin B-12 insufficiency and hyperhomocysteinemia were highly prevalent in CD patients. Recently, the significance of extra-intestinal complications of CD has been increasingly recognized, and our finding is likely to be of clinical importance.
- リンク情報
- ID情報
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- DOI : 10.6133/apjcn.022017.13
- ISSN : 0964-7058
- eISSN : 1440-6047
- Web of Science ID : WOS:000411922300013