論文

査読有り
2012年11月

Japanese Butterbur (Petasites japonicus) Leaves Increase Hepatic Oxidative Stress in Male Rats

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
  • Kyu-Ho Han
  • ,
  • Mitsuo Sekikawa
  • ,
  • Ken-ichiro Shimada
  • ,
  • Chi-Ho Lee
  • ,
  • Naoto Hashimoto
  • ,
  • Michihiro Fukushima

76
11
開始ページ
2026
終了ページ
2031
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1271/bbb.120294
出版者・発行元
TAYLOR & FRANCIS LTD

We investigated the adverse effects of Japanese butterbur leaves (Petasites japonicus, Compositae) in male F344/DuCrj rats. The rats were fed a control diet or a treatment diet containing 5% butterbur leaf powder for 4 weeks. No differences were observed in body weight gain, food intake or feed efficiency between treatments, but relative liver weight in the butterbur group was significantly higher than that of the control group. In addition, thiobarbituric acid reactive substances (TBARs) and glutathione levels in the serum and liver of the butterbur group were higher than those of the control group. Hepatic glutathione reductase and glutathione S-transferase activities and mRNA expression in the butterbur leaf group were higher than in the control group. Furthermore, hepatic cytochrome 2E1 mRNA expression was higher than in the control group. In vitro, an acetone extract of the butterbur leaf powder showed the strongest increase in TBARs level in a hepatic homogenate through 4d. Our findings suggest that feeding 5% butterbur leaf powder to rats can cause adverse effects by increasing oxidative stress.

リンク情報
DOI
https://doi.org/10.1271/bbb.120294
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23132561
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000312049200005&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84870214091&origin=inward
ID情報
  • DOI : 10.1271/bbb.120294
  • ISSN : 0916-8451
  • eISSN : 1347-6947
  • PubMed ID : 23132561
  • SCOPUS ID : 84870214091
  • Web of Science ID : WOS:000312049200005

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