論文

査読有り 筆頭著者 責任著者
2017年2月

Intraduodenal infusion of cyanidin-3-glucoside transiently promotes triglyceride excretion into bile in rats

NUTRITION RESEARCH
  • Naoto Hashimoto
  • ,
  • Kyu-Ho Han
  • ,
  • Michihiro Fukushima

38
開始ページ
34
終了ページ
42
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.nutres.2017.01.002
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Flavonoids purportedly have a role in improving lipid metabolism. In our preliminary study, highly concentrated flavonoid metabolites appeared in bile juice in rats, which also contains various lipids. Biliary flavonoid metabolites generally have amphiphilic properties, may influence lipid solubility, and possibly contribute to the improvement of dyslipidemia. However, the influence of biliary flavonoid metabolites on the biliary lipid profile is not well known. Therefore, we hypothesized that the amphiphilic property of biliary flavonoid metabolites alters biliary lipid profiles. To estimate the influence of flavonoids on the biliary lipid profile, we laparotomized rats under anesthesia, intraduodenally injected them with cyanidin-3-glucoside chloride (C3G) or quercetin, and analyzed their biliary metabolite concentrations for 2 hours. Concentrations of C3G and quercetin metabolites peaked at 30 minutes after the injection; those of quercetin were 6 to 10 times higher than those of C3G throughout the sampling period up to 2 hours. Biliary triglyceride (TG) concentrations were higher in the C3G group at 30 and 45 minutes; biliary cholesterol and phospholipid concentrations were lower in the quercetin group at 30 minutes than those in the control group. Hepatic TG content after the 2-hour sampling was lower in the C3G group than in the control group. These results suggest that C3G, but not quercetin, may transiently promote TG excretion into bile, with a reduction in hepatic TG content. This C3G effect may be involved in improvement of TG metabolism. (C) 2017 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.nutres.2017.01.002
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000399256800004&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85012249763&origin=inward
ID情報
  • DOI : 10.1016/j.nutres.2017.01.002
  • ISSN : 0271-5317
  • SCOPUS ID : 85012249763
  • Web of Science ID : WOS:000399256800004

エクスポート
BibTeX RIS