2019年12月
Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study
JOURNAL OF EPIDEMIOLOGY
- 巻
- 29
- 号
- 12
- 開始ページ
- 478
- 終了ページ
- 486
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2188/jea.JE20180098
- 出版者・発行元
- JAPAN EPIDEMIOLOGICAL ASSOC
Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb. Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM). Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or >= 0.35 UA/mL, and the metal levels were divided into quartiles.Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.
- リンク情報
- ID情報
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- DOI : 10.2188/jea.JE20180098
- ISSN : 0917-5040
- Web of Science ID : WOS:000502629600005