論文

2019年12月

Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study

JOURNAL OF EPIDEMIOLOGY
  • Mayumi Tsuji
  • Chihaya Koriyama
  • Yasuhiro Ishihara
  • Megumi Yamamoto
  • Kiwako Yamamoto-Hanada
  • Kumiko Kanatani
  • Yu Ait Bamai
  • Kazunari Onishi
  • Ayako Senju
  • Shunsuke Araki
  • Eiji Shibata
  • Seiichi Morokuma
  • Masafumi Sanefuji
  • Hiroshi Kitazawa
  • Mayako Saito
  • Masakazu Umezawa
  • Atsuto Onoda
  • Koichi Kusuhara
  • Rie Tanaka
  • Toshihiro Kawamoto
  • Hirohisa Saito
  • Reiko Kishi
  • Nobuo Yaegashi
  • Koichi Hashimoto
  • Chisato Mori
  • Shuichi Ito
  • Zentaro Yamagata
  • Hidekuni Inadera
  • Michihiro Kamijima
  • Takeo Nakayama
  • Hiroyasu Iso
  • Masayuki Shima
  • Yasuaki Hirooka
  • Narufumi Suganuma
  • Takahiko Katoh
  • 全て表示

29
12
開始ページ
478
終了ページ
486
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2188/jea.JE20180098
出版者・発行元
JAPAN EPIDEMIOLOGICAL ASSOC

Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb. Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM). Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or >= 0.35 UA/mL, and the metal levels were divided into quartiles.Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.

リンク情報
DOI
https://doi.org/10.2188/jea.JE20180098
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000502629600005&DestApp=WOS_CPL
ID情報
  • DOI : 10.2188/jea.JE20180098
  • ISSN : 0917-5040
  • Web of Science ID : WOS:000502629600005

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