論文

査読有り
2017年10月

Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses

NPJ schizophrenia
  • Pandey, Himani
  • ,
  • Bourahmoune, Katia
  • ,
  • Honda, Takato
  • ,
  • Honjo, Ken
  • ,
  • Kurita, Kazuki
  • ,
  • Sato, Tomohito
  • ,
  • Sawa, Akira
  • ,
  • Furukubo-Tokunaga, Katsuo

3
1
開始ページ
39
終了ページ
39
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41537-017-0040-6
出版者・発行元
NATURE PUBLISHING GROUP

Originally identified at the breakpoint of a (1;11)(q42.1; q14.3) chromosomal translocation in a Scottish family with a wide range of mental disorders, the DISC1 gene has been a focus of intensive investigations as an entry point to study the molecular mechanisms of diverse mental dysfunctions. Perturbations of the DISC1 functions lead to behavioral changes in animal models, which are relevant to psychiatric conditions in patients. In this work, we have expressed the human DISC1 gene in the fruit fly (Drosophila melanogaster) and performed a genetic screening for the mutations of psychiatric risk genes that cause modifications of DISC1 synaptic phenotypes at the neuromuscular junction. We found that DISC1 interacts with dnrx1, the Drosophila homolog of the human Neurexin (NRXN1) gene, in the development of glutamatergic synapses. While overexpression of DISC1 suppressed the total bouton area on the target muscles and stimulated active zone density in wild-type background, a partial reduction of the dnrx1 activity negated the DISC1-mediated synaptic alterations. Likewise, overexpression of DISC1 stimulated the expression of a glutamate receptor component, DGLURIIA, in wild-type back

リンク情報
DOI
https://doi.org/10.1038/s41537-017-0040-6
CiNii Articles
http://ci.nii.ac.jp/naid/120006366824
URL
http://hdl.handle.net/2241/00149164
ID情報
  • DOI : 10.1038/s41537-017-0040-6
  • ISSN : 2334-265X
  • CiNii Articles ID : 120006366824

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