2017年3月
Examination of the early wound healing process under different wound dressing conditions
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
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- 巻
- 123
- 号
- 3
- 開始ページ
- 310
- 終了ページ
- 319
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.oooo.2016.10.023
- 出版者・発行元
- ELSEVIER SCIENCE INC
Objective. Various types of wound-healing dressings have been used to assist in the healing of surgical wounds. We analyzed the wound-healing process in an animal model using different existing wound dressings.
Study design. Full-thickness defects were created using a biopsy punch on the backs of 7-week-old rats. The wounded areas were covered with NEOVEIL (polyglycolic acid [PGA]) or TERUDERMIS (collagen sponge [CS]) affixed using a rat jacket. The wound area, neo-epithelium length, and a-smooth muscle actin (a-SMA) expression were evaluated and compared among the control, PGA, and CS groups.
Results. The wound areas in the control group on days 4 and 7 were significantly smaller than those in the PGA and CS groups. The expression of a-SMA in granulation tissue peaked on day 4 for all groups. The expression of a-SMA in the control group on days 4 and 7 after injury was greater than in the PGA and CS groups. However, there was no significant difference in the expression of a-SMA between the PGA and CS groups.
Conclusions. In this study, PGA and CS suppressed wound contracture and reduced expression of a-SMA in wound areas. However, PGA and CS did not affect the neo-epithelium length at the wound site.
Study design. Full-thickness defects were created using a biopsy punch on the backs of 7-week-old rats. The wounded areas were covered with NEOVEIL (polyglycolic acid [PGA]) or TERUDERMIS (collagen sponge [CS]) affixed using a rat jacket. The wound area, neo-epithelium length, and a-smooth muscle actin (a-SMA) expression were evaluated and compared among the control, PGA, and CS groups.
Results. The wound areas in the control group on days 4 and 7 were significantly smaller than those in the PGA and CS groups. The expression of a-SMA in granulation tissue peaked on day 4 for all groups. The expression of a-SMA in the control group on days 4 and 7 after injury was greater than in the PGA and CS groups. However, there was no significant difference in the expression of a-SMA between the PGA and CS groups.
Conclusions. In this study, PGA and CS suppressed wound contracture and reduced expression of a-SMA in wound areas. However, PGA and CS did not affect the neo-epithelium length at the wound site.
- リンク情報
- ID情報
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- DOI : 10.1016/j.oooo.2016.10.023
- ISSN : 2212-4403
- eISSN : 1528-395X
- PubMed ID : 28094213
- Web of Science ID : WOS:000398951300010