論文

査読有り
2017年3月

Examination of the early wound healing process under different wound dressing conditions

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
  • Toshiro Kibe
  • ,
  • Takashi Koga
  • ,
  • Kazuhide Nishihara
  • ,
  • Takao Fuchigami
  • ,
  • Takuya Yoshimura
  • ,
  • Tetsushi Taguchi
  • ,
  • Norifumi Nakamura

123
3
開始ページ
310
終了ページ
319
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.oooo.2016.10.023
出版者・発行元
ELSEVIER SCIENCE INC

Objective. Various types of wound-healing dressings have been used to assist in the healing of surgical wounds. We analyzed the wound-healing process in an animal model using different existing wound dressings.
Study design. Full-thickness defects were created using a biopsy punch on the backs of 7-week-old rats. The wounded areas were covered with NEOVEIL (polyglycolic acid [PGA]) or TERUDERMIS (collagen sponge [CS]) affixed using a rat jacket. The wound area, neo-epithelium length, and a-smooth muscle actin (a-SMA) expression were evaluated and compared among the control, PGA, and CS groups.
Results. The wound areas in the control group on days 4 and 7 were significantly smaller than those in the PGA and CS groups. The expression of a-SMA in granulation tissue peaked on day 4 for all groups. The expression of a-SMA in the control group on days 4 and 7 after injury was greater than in the PGA and CS groups. However, there was no significant difference in the expression of a-SMA between the PGA and CS groups.
Conclusions. In this study, PGA and CS suppressed wound contracture and reduced expression of a-SMA in wound areas. However, PGA and CS did not affect the neo-epithelium length at the wound site.

リンク情報
DOI
https://doi.org/10.1016/j.oooo.2016.10.023
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28094213
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000398951300010&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.oooo.2016.10.023
  • ISSN : 2212-4403
  • eISSN : 1528-395X
  • PubMed ID : 28094213
  • Web of Science ID : WOS:000398951300010

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