論文

査読有り
2019年7月1日

Co-existing of Neuromyelitis Optica and Fulminant Type 1 Diabetes.

Internal medicine (Tokyo, Japan)
  • Takanobu Saheki
  • ,
  • Hitomi Imachi
  • ,
  • Tomohiro Ibata
  • ,
  • Kensuke Fukunaga
  • ,
  • Yuki Yoshioka
  • ,
  • Toshihiro Kobayashi
  • ,
  • Seisuke Sato
  • ,
  • Kazuko Mizumoto
  • ,
  • Takuo Yoshimoto
  • ,
  • Jingya Lyu
  • ,
  • Tao Dong
  • ,
  • Koji Murao

58
13
開始ページ
1913
終了ページ
1916
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.2353-18

The patient was a 71-year-old woman with aquaporin-4-antibody positive neuromyelitis optica (NMO), with no history of diabetes. On admission, although she showed an extremely elevated plasma glucose level (1,080 mg/dL), her hemoglobin A1c level was low (7.1%), which indicated the rapid progression of diabetes. She also showed ketoacidosis and had a human leukocyte antigen haplotype, DRB1*09:01-DQB1*03:03 associated with Fulminant type 1 diabetes (FT1D). Based on these results, the patient was diagnosed with FT1D. We herein describe the first reported case of a patient with FT1D with NMO, which raises the possibility that T-cell-mediated autoimmunity is involved in the pathogenesis of both FT1D and NMO.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.2353-18
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30918186
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663534

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