ISHIMARU Yuki

J-GLOBAL         Last updated: Dec 6, 2019 at 10:51
 
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Name
ISHIMARU Yuki
E-mail
ishimarupharm.setsunan.ac.jp
Affiliation
Setsunan University
Section
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
Job title
Assistant Professor
Research funding number
80611607

Research Areas

 
 

Published Papers

 
Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-κB p65 through the formation of dopamine quinone in microglia.
Yoshioka Y, Sugino Y, Shibagaki F, Yamamuro A, Ishimaru Y, Maeda S.
Eur J Pharmacol.   866(5) 172826   Jan 2020   [Refereed]
Yuki Ishimaru, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka & Sadaaki Maeda
Scientific Reports   7(1) 15062   Nov 2017   [Refereed]
虚血性網膜症モデルマウスの網膜で生じる異常血管新生に対してapelin受容体アンタゴニストが抑制作用を示すことを明らかにした。
Ishimaru Y, Sumino A, Kajioka D, Shibagaki F, Yamamuro A, Yoshioka Y, Maeda S.
J Pharmacol Sci.   133(1) 34-41   Jan 2017   [Refereed]
Yoshioka Y, Kadoi H, Yamamuro A, Ishimaru Y, Maeda S.
Eur J Pharmacol.   772 51-61   Feb 2016   [Refereed]
ヒトアストロサイトーマU251-MG細胞において、ノルアドレナリンがβ3受容体を介してグルタミン酸-システイン リガーゼの発現を誘導することにより、細胞内グルタチオン量を増加させることを明らかにした。
Yoshioka Y, Sugino Y, Tozawa A, Yamamuro A, Kasai A, Ishimaru Y, Maeda S.
J Pharmacol Sci.   130(2) 51-59   Feb 2016   [Refereed]
マウスミクログリア株BV-2細胞において、ドパミンがキノン化を介してリポポリサッカライドにより誘導される一酸化窒素の産生を阻害することを明らかにした。

Misc

 
Apelin protects against loss of retinal ganglion cells in a glaucoma model mouse
Yuki Ishimaru, Akihide Sumino, Sadaaki Maeda
Jpn J Ocular Pharmacol.   29 41-43   Aug 2015   [Refereed]

Conference Activities & Talks

 
Neuroprotective effect of the endogenous peptide apelin on the retinal ganglion cell death in diabetes model mouse
Fumiya Shibagaki, Yuki Ishimaru , Mayu Suzuki , Akiko Yamamuro , Yasuhiro Yoshioka , Sadaaki Maeda
ISN-ASN 2019   4 Aug 2019   
L-Theanine inhibits the proliferation of neural cell lines via an L-glutamine transporter Slc38a1
Sadaaki Maeda, Yuka Watanabe, Shuhei Araki, Tamika Sudo, Sayuki Yoshikawa, Mitsuhiro Shibata, Akiko Yamamuro, Yuki Ishimaru, Yasuhiro Yoshioka, Toshihiko Kinjyo, Nobuyuki Kuramoto, Yukio Yoneda
ISN-ASN 2019   4 Aug 2019   
DA attenuates LPS-induced cytokine expression by inhibiting the microtubule-dependent nuclear transport of NF-kB p65 in BV-2 cells
Yasuhiro Yoshioka, Yuta Sugino , Fumiya Shibagaki , Akiko Yamamuro , Yuki Ishimaru , Sadaaki Maeda
ISN-ASN 2019   4 Aug 2019   
An apelin receptor agonist protects against retinal neuronal cell death induced by N-methyl-D-aspartic acid in mice
Yuki Ishimaru, Hiroko Konishi , Toru Kuriyama , Fumiya Shibagaki , Akiko Yamamuro , Yasuhiro Yoshioka , Sadaaki Maeda
ISN-ASN 2019   4 Aug 2019   
An apelin receptor antagonist inhibits pathological retinal angiogenesis in a mouse model of ischemic retinopathy
Fumiya Shibagaki, Yuki Ishimaru, Hiroko Konishi, Mayu Suzuki, Yuya Fujii, Akiko Yamamuro, Yasuhiro Yoshioka, and Sadaaki Maeda
18th World Congress of Basic and Clinical Pharmacology   1 Jul 2018   

Works

 
A new neuroprotective agent for the treatment of retinal diseases
ISHIMARU Yuki   The Others   Aug 2019 - Aug 2019
Apelin/APJ system as a novel therapeutic target in ischemic retinopathy
The Others   Aug 2013