大場基 (Motoi Ohba) - マイポータル

Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms

Toshimitsu Yamaoka, Motoi Ohba, Tohru Ohmori

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18(11) 2017年11月査読有り招待有り

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Toshimitsu Yamaoka, Motoi Ohba, Satoru Arata, Tohru Ohmori

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (126) 2017年8月査読有り

Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation

Toshimitsu Yamaoka, Tohru Ohmori, Motoi Ohba, Satoru Arata, Yasunori Murata, Sojiro Kusumoto, Koichi Ando, Hiroo Ishida, Tsukasa Ohnishi, Yasutsuna Sasaki

MOLECULAR CANCER RESEARCH 15(7) 915-928 2017年7月査読有り

Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation

Toshimitsu Yamaoka, Tohru Ohmori, Motoi Ohba, Satoru Arata, Yasunari Kishino, Yasunori Murata, Sojiro Kusumoto, Hiroo Ishida, Takao Shirai, Takashi Hirose …

MOLECULAR CANCER THERAPEUTICS 15(12) 3040-3054 2016年12月査読有り

Up-regulation of Syndecan-4 contributes to TGF-β1-induced epithelial to mesenchymal transition in lung adenocarcinoma A549 cells.

Toba-Ichihashi Y, Yamaoka T, Ohmori T, Ohba M

Biochemistry and biophysics reports 5 1-7 2016年3月1日査読有り

Role of protein kinase C-η in cigarette smoke extract-induced apoptosis in MRC-5-cells.

Son ES, Kyung SY, Lee SP, Jeong SH, Shin JY, Ohba M, Yeo EJ, Park JW

Human & experimental toxicology 34(9) 869-877 2015年9月査読有り

Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients.

Hiroaki Ito, Katsuyuki Hasegawa, Yuuki Hasegawa, Tadashi Nishimaki, Kazuyoshi Hosomichi, Satoshi Kimura, Motoi Ohba, Hiroshi Yao, Manabu Onimaru, Ituro Inoue …

Scientific reports 5 10455-10455 2015年5月21日査読有り

Improved long-term culture of epidermal stem cells utilizing CD200R-expressing feeder cells.

The Showa University Journal of Medical Sciences. 27(2) 83-91 2015年3月査読有り

Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772.

Chattopadhyay R, Dyukova E, Singh NK, Ohba M, Mobley JA, Rao GN

The Journal of biological chemistry 289(6) 3148-3163 2014年2月査読有り

B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor

Togo Ikuta, Motoi Ohba, Christos C. Zouboulis, Yoshiaki Fujii-Kuriyama, Kaname Kawajiri

JOURNAL OF DERMATOLOGICAL SCIENCE 58(3) 211-216 2010年6月査読有り

Activation of Proteinase-Activated Receptor 2 Stimulates Soluble Vascular Endothelial Growth Factor Receptor 1 Release via Epidermal Growth Factor Receptor Transactivation in Endothelial Cells

Bahjat Al-Ani, Peter W. Hewett, Melissa J. Cudmore, Takeshi Fujisawa, Mahmoud Saifeddine, Hannah Williams, Wenda Ramma, Samir Sissaoui, Padma-Sheela Jayaraman, Motoi Ohba …

HYPERTENSION 55(3) 689-U41 2010年3月査読有り

Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes

Nagisa Kamioka, Tomoko Akahane, Yoko Kohno, Toshio Kuroki, Masafumi Iijima, Ikuo Honma, Motoi Ohba

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394(1) 106-111 2010年3月査読有り

Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes

Kyungmoo Yea, Jaeyoon Kim, Jong Hyuk Yoon, Taewan Kwon, Jong Hyun Kim, Byoung Dae Lee, Hae-Jeong Lee, Seung Jae Lee, Jong-In Kim, Taehoon G. Lee …

JOURNAL OF BIOLOGICAL CHEMISTRY 284(49) 33833-33840 2009年12月査読有り

Functional Characterization of IL-17F as a Selective Neutrophil Attractant in Psoriasis

Hideaki Watanabe, Mio Kawaguchi, Sawa Fujishima, Miyoko Ogura, Satoshi Matsukura, Hiroko Takeuchi, Motoi Ohba, Hirohiko Sueki, Fumio Kokubu, Nobuyuki Hizawa …

JOURNAL OF INVESTIGATIVE DERMATOLOGY 129(3) 650-656 2009年3月査読有り

Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis.

Park JW, Kim HP, Lee SJ, Wang X, Wang Y, Ifedigbo E, Watkins SC, Ohba M, Ryter SW, Vyas YM …

Journal of immunology (Baltimore, Md. : 1950) 180(7) 4668-4678 2008年4月査読有り

A protein kinase C epsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2

Rivka Steinberg, Olivier A. Harari, Elaine A. Lidington, Joseph J. Boyle, Mahrokh Nohadani, Allen M. Samarel, Motoi Ohba, Dorian O. Haskard, Justin C. Mason

JOURNAL OF BIOLOGICAL CHEMISTRY 282(44) 32288-32297 2007年11月査読有り

Activation of protein kinase C zeta mediates luteinizing hormone- or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary

Jae-Il Park, Sun-Gyun Kim, Jang-Soo Chun, You-Mi Seo, Mi-Jin Jeon, Motoi Ohba, Hyun-Jin Kim, Sang-Young Chun

MOLECULAR AND CELLULAR ENDOCRINOLOGY 270(1-2) 79-86 2007年5月査読有り

Pituitary adenylate cyclase-activating polyp eptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C

Jun Watanabe, Motoi Ohba, Fusako Ohno, Sakae Kikuyama, Masahisa Nakamura, Kazuyasu Nakaya, Akira Arimura, Seiji Shioda, Shigeo Nakajo

JOURNAL OF NEUROSCIENCE RESEARCH 84(8) 1645-1655 2006年12月査読有り

A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated induction of decay-accelerating factor on human endothelial cells

EA Lidington, R Steinberg, AR Kinderlerer, RC Landis, M Ohba, A Samarel, DO Haskard, JC Mason

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 289(6) C1437-C1447 2005年12月査読有り

Novel functions of the phospholipase D2-phox homology domain in protein kinase C zeta activation

JH Kim, JH Kim, M Ohba, PG Suh, SH Ryu

MOLECULAR AND CELLULAR BIOLOGY 25(8) 3194-3208 2005年4月査読有り

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