2007年
Carbohydrate-appended curdlans as a new family of glycoclusters with binding properties both for a polynucleotide and lectins
ORGANIC & BIOMOLECULAR CHEMISTRY
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- 巻
- 5
- 号
- 15
- 開始ページ
- 2404
- 終了ページ
- 2412
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/b703720a
- 出版者・発行元
- ROYAL SOC CHEMISTRY
beta-1,3-Glucans having carbohydrate-appendages (alpha-D-mannoside, N-acetyl-beta-D-glucosaminide and beta-lactoside) at the C6-position of every repeating unit can be readily prepared from curdlan (a linear beta-1,3-glucan) through regioselective bromination/azidation to afford 6-azido-6-deoxycurdlan followed by chemo-selective Cu(I)-catalyzed [3 + 2]-cycloaddition with various carbohydrate modules having a terminal alkyne. The resultant carbohydrate-appended curdlans can interact with polycytosine to form stable macromolecular complexes consistent with two polysaccharide strands and one polycytosine strand. Furthermore, these macromolecular complexes show strong and specific affinity toward carbohydrate-binding proteins ( lectins). Therefore, one can utilize these carbohydrate-appended curdlans as a new family of glycoclusters.
- リンク情報
- ID情報
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- DOI : 10.1039/b703720a
- ISSN : 1477-0520
- PubMed ID : 17637960
- Web of Science ID : WOS:000248121800019