The prognosis of ventricular arrhythmia after myocardial infarction is fatal. Veughan Williams Class I drugs are usually selected to treat it, but in some cases they are not effective. In addition, Class I drugs are difficult to use for patients with poor cardiac function because of their negative inotropic effects. Class III drugs Nifekalant was effective for drug-resistant ventricular tachycardia after myocardial infarction in 3 cases. The drug does not suppress cardiac function, and is useful for drug-resistant ventricular arrhythmia in patient with poor cardiac function.