MISC

2012年9月

Effects of Statin Therapy on Abdominal Aortic Aneurysm Growth: A Meta-analysis and Meta-regression of Observational Comparative Studies

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
  • H. Takagi
  • ,
  • H. Yamamoto
  • ,
  • K. Iwata
  • ,
  • S. Goto
  • ,
  • T. Umemoto

44
3
開始ページ
287
終了ページ
292
記述言語
英語
掲載種別
DOI
10.1016/j.ejvs.2012.06.021
出版者・発行元
W B SAUNDERS CO LTD

Objective: To determine whether statin therapy reduces the growth rate of small abdominal aortic aneurysms (AAAs).
Design: A meta-analysis and a meta-regression of comparative studies.
Materials: Eligible studies were randomized controlled trials or observational comparative studies of statin therapy versus placebo or no statin, enrolling individuals with small (<55 mm in diameter) AAAs and reporting AAA growth rate as an outcome.
Methods: Study-specific estimates (standardized mean differences [SMDs]) were combined in the fixed- and random-effects model.
Results: Seven adjusted and 4 unadjusted observational comparative studies enrolling 4647 patients with a small AAA were identified. Pooled analysis of all 11 studies suggested a significant reduction in AAA growth rate among patients assigned to statin therapy versus no statin (SMD, -0.420; 95% confidence interval [CI] -0.651 to -0.189). Combining the 7 high-quality studies providing adjusted data for growth rates generated an attenuated but still statistically significant result favoring statin therapy (SMD, -0.367; 95% CI, -0.566 to -0.168). The meta-regression coefficient for the baseline diameter was statistically significant (-0.096; 95% CI, -0.132 to -0.061).
Conclusion: Statin therapy is likely effective in prevention of the growth of small AAAs, and may be more beneficial as the baseline diameter increases. (C) 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 69

リンク情報
DOI
https://doi.org/10.1016/j.ejvs.2012.06.021
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22824348
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000309303500013&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865459649&origin=inward
ID情報
  • DOI : 10.1016/j.ejvs.2012.06.021
  • ISSN : 1078-5884
  • PubMed ID : 22824348
  • SCOPUS ID : 84865459649
  • Web of Science ID : WOS:000309303500013

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