アリフセインハッサン (Aly HusseinHassan) - マイポータル

基本情報

所属: 厚生労働省国立感染症研究所

学位: PhD(Kyoto University)
MD(Cairo University)

J-GLOBAL ID: 201801008003285625
researchmap会員ID: B000330985

Position: Senior Research Scientist, Virology 2 department.
Research Interest: Virology, Viral Immunology, RNA Biology and viral diseases.

研究キーワード

研究分野

ライフサイエンス / ウイルス学 / Viral Immunology

経歴

2012年3月 - 現在

National Institute of Infectious Diseases, Virology 2 department, Senior Research Scientist
2010年4月 - 2012年2月

Hokkaido University, Microbiology and Immunology, Assistant Professor
2007年4月 - 2010年3月

Kyoto University, Institute for Virus Research, Post Doc
1997年9月 - 2003年3月

National Hepatology and Tropical Medicine Research Institute, Internal Medicine, Resident

学歴

2003年4月 - 2007年3月

Kyoto University, Institute for virus research, PhD in medical science
1997年9月 - 1999年8月

Cairo University, Tropical Medicine, Master Degree in Tropical Medicine
1988年9月 - 1995年8月

Cairo University, Medical School, MD

委員歴

2021年3月 - 現在

American Society for Microbiology
2019年9月 - 現在

The American Society for Virology
2017年9月 - 現在

The Egyptian Society for Virology
2009年4月 - 現在

The Japanese Society for Virology

受賞

2014年

Liver Forum in Kyoto Award, Japanese Society for Viral Hepatitis

アリフセインハッサン
2011年

Post-Doctoral Scholarship, Japanese society for promotion of Science (JSPS)

アリフセインハッサン
2004年

Gakushu Shoreihi scholarship, Japanese Ministry of Education, Culture, Sports, Science and Technology,

アリフセインハッサン

論文

A novel synthetic bile acid derivative inhibits hepatitis B virus infection at entry step by interfering with the oligomerization of sodium taurocholate co-transporting polypeptide

Gede Ngurah Rsi Suwardana, Takayuki Abe, Lin Deng, Chieko Matsui, Takashi Okitsu, Takeshi Yamada, Manabu Hatano, Pattama Wiriyasermkul, Shushi Nagamori, Sameh A. Gad …

Antiviral Research 243 106267-106267 2025年11月査読有り
A synonymous mutation in the preS2 region enhances production of infectious hepatitis B virus

Asako Murayama, Norie Yamada, Masaaki Toyama, Hussein Hassan Aly, Hironori Nishitsuji, Kunitada Shimotohno, Masanori Isogawa, Takanobu Kato

Virology 612 110692-110692 2025年11月査読有り
RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking

Sameh A. Gad, Doaa A. Abo Elwafa, Saied A. Hussein, Kento Fukano, Takanobu Kato, Ikuo Shoji, Kazuaki Chayama, Masamichi Muramatsu, Masanori Isogawa, Takaji Wakita …

Antiviral Research 240 106214-106214 2025年8月査読有り責任著者
Exploring the tolerable region for HiBiT tag insertion in the hepatitis B virus genome

Asako Murayama, Hitomi Igarashi, Norie Yamada, Hussein Hassan Aly, Masaaki Toyama, Masanori Isogawa, Tetsuro Shimakami, Takanobu Kato

mSphere 9(10) 2024年10月29日査読有り
Antiviral effect of peptoids on hepatitis B virus infection in cell culture.

Asako Murayama, Hitomi Igarashi, Norie Yamada, Hussein Hassan Aly, Natalia Molchanova, Jennifer S Lin, Hironori Nishitsuji, Kunitada Shimotohno, Masamichi Muramatsu, Annelise E Barron …

Antiviral research 223 105821-105821 2024年3月査読有り
Prediction and surveillance of de novo HCC in patients with compensated advanced chronic liver disease after hepatitis C virus eradication with direct antiviral agents

Ashraf Elbahrawy, Hassan Atalla, Abdulla A. Mahmoud, Ahmed Eliwa, Alaa Alsawak, Mohamed Alboraie, Ali Madian, Ahmed Alashker, Sadek Mostafa, Ahmed Alwassief …

Frontiers in Virology 3 2023年10月24日査読有り最終著者責任著者
Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication.

Adi Ariffianto, Lin Deng, Takayuki Abe, Chieko Matsui, Masahiko Ito, Akihide Ryo, Hussein Hassan Aly, Koichi Watashi, Tetsuro Suzuki, Masashi Mizokami …

Journal of virology 97(10) e0128723 2023年10月6日査読有り
Recent Advances in Protective Vaccines against Hepatitis Viruses: A Narrative Review

Ashraf Elbahrawy, Hassan Atalla, Mohamed Alboraie, Ahmed Alwassief, Ali Madian, Mohammed El Fayoumie, Ashraf A. Tabll, Hussein H. Aly

Viruses 15(1) 214-214 2023年1月12日査読有り最終著者責任著者
Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

Ayaka Washizaki, Asako Murayama, Megumi Murata, Tomoko Kiyohara, Keigo Yato, Norie Yamada, Hussein Hassan Aly, Tomohisa Tanaka, Kohji Moriishi, Hironori Nishitsuji …

Nature Communications 13(1) 5207-5207 2022年9月5日査読有り
The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

Sameh A. Gad, Masaya Sugiyama, Masataka Tsuge, Kosho Wakae, Kento Fukano, Mizuki Oshima, Camille Sureau, Noriyuki Watanabe, Takanobu Kato, Asako Murayama …

PLOS Pathogens 18(3) e1009983-e1009983 2022年3月21日査読有り最終著者責任著者
Interferon-gamma induced APOBEC3B contributes to Merkel cell polyomavirus genome mutagenesis in Merkel cell carcinoma.

Lusheng Que, Yingfang Li, Teruki Dainichi, Iwao Kukimoto, Tomoaki Nishiyama, Yuri Nakano, Kaori Shima, Tadaki Suzuki, Yuko Sato, Shinichi Horike …

The Journal of investigative dermatology 142(7) 1793-1803 2021年12月27日査読有り
Current situation of viral hepatitis in Egypt

Ashraf Elbahrawy, Marwa K. Ibrahim, Ahmed Eliwa, Mohamed Alboraie, Ali Madian, Hussein Hassan Aly

Microbiology and Immunology 2021年8月21日査読有り招待有り最終著者責任著者
Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus

Xin Zheng, Rui Guo, Qingbo Liu, Kousho Wakae, Noriyuki Watanabe, Kento Fukano, Lusheng Que, Yingfang Li, Hussein H. Aly, Koichi Watashi …

Biochemical and Biophysical Research Communications 567 1-8 2021年8月査読有り
Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure

Takashi Honda, Norie Yamada, Asako Murayama, Masaaki Shiina, Hussein Hassan Aly, Asuka Kato, Takanori Ito, Yoji Ishizu, Teiji Kuzuya, Masatoshi Ishigami …

Cellular and Molecular Gastroenterology and Hepatology 12(5) 1583-1598 2021年8月査読有り
MafF Is an Antiviral Host Factor That Suppresses Transcription from Hepatitis B Virus Core Promoter

Marwa K. Ibrahim, Tawfeek H. Abdelhafez, Junko S. Takeuchi, Kosho Wakae, Masaya Sugiyama, Masataka Tsuge, Masahiko Ito, Koichi Watashi, Mohamed El Kassas, Takanobu Kato …

Journal of Virology 95(15) e0076721 2021年7月12日査読有り最終著者責任著者
MCPIP1 reduces HBV-RNA by targeting its epsilon structure

Yingfang Li, Lusheng Que, Kento Fukano, Miki Koura, Kouichi Kitamura, Xin Zheng, Takanobu Kato, Hussein Hassan Aly, Koichi Watashi, Senko Tsukuda …

Scientific Reports 10(1) 20763-20763 2020年12月査読有り
N-terminal PreS1 Sequence Regulates Efficient Infection of Cell Culture-generated Hepatitis B Virus.

Asako Murayama, Norie Yamada, Yoshiki Osaki, Masaaki Shiina, Hussein Hassan Aly, Masashi Iwamoto, Senko Tsukuda, Koichi Watashi, Mami Matsuda, Ryosuke Suzuki …

Hepatology (Baltimore, Md.) 73(2) 520-532 2020年5月23日査読有り
Anti-Viral Effects of Interferon-λ3 on Hepatitis B Virus Infection in Cell Culture.

Yamada N, Murayama A, Shiina M, Aly HH, Iwamoto M, Tsukuda S, Watashi K, Tanaka T, Moriishi K, Nishitsuji H …

Hepatology research : the official journal of the Japan Society of Hepatology 50(3) 283-291 2019年11月査読有り
Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA.

Deng L, Gan X, Ito M, Chen M, Aly HH, Matsui C, Abe T, Watashi K, Wakita T, Suzuki T …

Journal of virology 93(6) 2019年3月査読有り
Hepatitis B Virus Genotype-Dependent Vulnerability of Infected Cells to Immune Reaction in the Early Phase of Infection.

Masaaki Shiina, Norie Yamada, Ryuichi Sugiyama, Asako Murayama, Hussein Hassan Aly, Masamichi Muramatsu, Takaji Wakita, Michio Imawari, Takanobu Kato

Frontiers in microbiology 10 2427-2427 2019年査読有り

もっとみる

MISC

Induction of neutralization E2 antibody by immunization of recombinant E2 proteins

Noriyuki Watanabe, Tomoko Date, Hussein H. Aly, Hideki Aizaki, Takaji Wakita

HEPATOLOGY 66 466A-466A 2017年10月
Induction of neutralization E2 antibody by immunization of recombinant E2 proteins

Noriyuki Watanabe, Nanako Aihara, Tomoko Date, Hussein Hassan Aly, Hideki Aizaki, Takaji Wakita

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 31 380-381 2016年11月
ヒト初代B細胞におけるHCVcc感染

中井正人, 伊藤淳, 常松聖司, 佐藤史幸, 佃曜子, 寺下勝巳, 荘拓也, 須田剛生, 夏井坂光輝, 小川浩司 …

日本消化器病学会雑誌 112(臨増総会) A354-A354 2015年3月
Identification of signal pathway involved in infectious Hepatitis C virus (HCV) particle production

Yuichi Abe, Hussein H. Aly, Takaji Wakita, Kunitada Shimotohno, Makoto Hijikata

The 6th International symposium of institute network. Tokyo, Japan 2011年6月9日査読有り
IRF7 dependent IFN-alpha response in the early phase of the viral infected hepatocytes

Yue Qi, Hussein H. Aly, Chieko Tsutsui, Takashi Fujita, Makoto Hijikata

17th International symposium on hepatitis Cvirusand related viruses. Yokohama, Japan 2010年9月10日査読有り
Drug screening of blood-borne HCV using 3D cultured immortalized human hepatocytes

Hussein H. Aly, Kunitada Shimotohno, Makoto Hijikata

16th International symposium on hepatitis Cvirusand related viruses. Nice, France 2009年10月3日査読有り
TLR8 induces RIG-I gene expression and efficient interferon response against HCV infection in human hepatocytes

Hussein H. Aly, Chieko Tsutsui, Yue Qi, Yukihiro Kushima, Takashi Fujita, Kunitada Shimotohno, Makoto Hijikata

16th International symposium on hepatitis Cvirusand related viruses. Nice, France 2009年10月3日査読有り
Development of the novel in vitro system supporting the entire life cycle of natural HCV infection

Hussein H. Aly, Tatsuya Yamaguchi, Yue Qi, Kunitada Shimotohno, Makoto Hijikata

15th International symposium on hepatitis C Virus & related viruses. San Antonio USA 2008年10月5日査読有り
Serim derived HCV infection, replication, and particle production in immortalized primary human hepatocutes

Hussein H. Aly, Kunitada Shimotohno, Makoto Hijikata

14th International congress of Virology. Istanbul Turkey 2008年8月10日査読有り
In vitro infection of immortalized human hepatocytes by hepatitis B virus and its application to anti-viral treatment

Yasuhito Tanaka, Tatsuya Yamaguchi, Masaya Segawa, Masaya Sugiyama, Makoto Hijikata, Hussein Hassan Aly, Kunitada Shimotohno, Masashi Mizokami

HEPATOLOGY 46(4) 635A-635A 2007年10月
A nobel culture system for HCV infection and replication

Hussein H. Aly, Makoto Hijikata, Kunitada Shimotohno

14th International symposium on hepatitis C Virus & related viruses. Glasgow UK 2007年9月9日査読有り

講演・口頭発表等

Development of anti-hepatitis B virus drugs, novel trends and possibilities

Hussein H ALy

Antimicrobials: Novel trends and challenges, Seminar, Gastroenterology, Azhar University, Egypt 2023年11月13日招待有り
New advances in Hepatitis B virus treatment, a link between research and drug development

Hussein H Aly

The 30th International Conference of the Egyptian Society for Medical Microbiology (ESMM) in Association with the American Society for Microbiology (ASM) 2023年9月28日招待有り
DHX35, RNA Helicase Inhibits Hepatitis B Virus Replication by Targeting Pregenomic RNA. Oral presentation

Saied A.Hussein, Abdulla A. Mahmoud, Hussein H. Aly

The 70th Annual Meeting of the Japanese Society for Virology 2023年9月27日
DHX35 targets pgRNA for HBV restriction

Saied A. Hussein, Hussein H. Aly

2023 international HBV meeting 2023年9月20日
THE IDENTIFICATION OF NEW HOST FACTORS REGULATING THE LIFE CYCLE OF HEPATITIS B VIRUS

Saied A. Hussein, Hussein H Aly

Global Hepatitis Summit 2023年4月26日
DHX35, a DEAD/H box helicase restricting HBV replication

Saied A. Hussein, Hussein H Aly

The 9th Japan-Taiwan-Korea HBV Research Symposium 2023年4月2日招待有り
The identification of host factors affecting HBV infection and its use to develop novel anti-HBV drugs.

Hussein H Aly, Marwa K. Ibrahim, Sameh A. Gad, Saed Adeel

The 29th International Conference of the Egyptian Society for Medical Microbiology (ESMM) in Association with the American Society for Microbiology (ASM). 2022年9月2日招待有り
HBV/HDV INTERNALIZATION REQUIRES KINESIN KIF4 EXPRESSION WHICH REGULATES SURFACE NTCP LOCALIZATION AND CAN BE TARGETED BY RXR AGONISTS IN VITRO

Sameh A. Gad, Takanobu Kato, Kunitada Shimotohno, Ikuo Shoji, Kazuaki Chayama, Saied A. Hussein, Masamichi Muramatsu, Takaji Wakita, Hussein H. Aly

International Union of Microbiological Societies, (IUMS 2022)
Kinesin KIF4 is a possible therapeutic host target and key regulator for surface localization of NTCP, and HBV/HDV infection

Sameh A. Gad, Masaya Sugiyama, Masataka Tsuge, Kosho Wakae, Kento Fukano, Noriyuki Watanabe, Takanobu Kato, Asako Murayama, Yingfang Li, Ikuo Shoji, Kunitada Shimotohno, Kazuaki Chayama, Masamichi Muramatsu, Takaji Wakita, Tomoyoshi Nozaki, Hussein H. Aly

The 68th Annual Meeting of the Japanese Society for Virology 2021年11月16日
The current problem of chronic hepatitis B and its treatment options

Hussein H. Aly

DECOTA program, Universita Airllanga 2021年11月招待有り
Kinesin KIF4 is a key regulator for surface localization of NTCP, and HBV/HDV infection

Sameh A. Gad, Masaya Sugiyama, Masataka Tsuge, Kosho Wakae, Kento Fukano, Noriyuki Watanabe, Takanobu Kato, Asako Murayama, Yingfang Li, Ikuo Shoji, Kunitada Shimotohno, Kazuaki Chayama, Masamichi Muramatsu, Takaji Wakita, Tomoyoshi Nozaki, Hussein H. Aly

2021 International Meeting, Biology of the Hepatitis B and D Viruses 2021年9月28日
KIF4a, a new host factor required for surface localization of NTCP, and HBV/HDV infection

Sameh Ali Gad, Takanobu Kato, Masamichi Muramatsu, Kazuaki Chayama, Takaji Wakita, Hussein H Aly

17th Hiroshima Liver project research center symposium 2021年6月招待有り
MafF is a novel host restriction factor for HBV which suppresses transcription from HBV-core promoter

Marwa Ibrahim, Aly HusseinHassan

American Society for Virology, (because of Covid19 we presented our talk online) 2020年
The IL-1 β induced (MafF) is an important regulator of HBV core promoter activity.

Marwa Ibrahim, Aly HusseinHassan

The 67th Annual Meeting of the Japanese Society for Virology 2019年
MafF is a key player of IL-1β-induced suppression of transcription from HBV-core promoter, and the resulting suppression of viral replication. 2019 International Meeting, molecular Biology of Hepatitis B virus

Marwa Ibrahim, Aly HusseinHassan

International HBV Meeting 2019年
IL-1β/ATF3-mediated induction of Ski2 expression enhances hepatitis B virus x mRNA degradation.

アリフセインハッサン

66th Annual Meeting of the Japanese Society for Virology 2018年11月28日
A Balancing Act: Hepatic Antiviral Innate Immune Defense and Viral Evasion

アリフセインハッサン

20th international conference on emerging infectious diseases in the Pacific rim 2018年1月10日招待有り
HBx mRNA degradation by RNA exosome which results X protein regulation in HBV infected cells.

アリフセインハッサン

20th international conference on emerging infectious diseases in the Pacific rim 2018年1月9日招待有り
Post-Transcriptional Regulation of Hepatitis B Virus (HBV) x mRNA Degradation and Its Potential As a New Anti-HBV Approach

Aly HusseinHassan

American Association for the Study of Liver Diseases, The Liver Meeting 2018年
Establishment of Infectious Genotype 4a HCVcc

Noriyuki Watanabe, Takaya Suzuki, Tomoko Date, Su Su Hmwe, Hussein Aly, Hideki Aizaki, Masaya Sugiyama, Masashi Mizokami, Mohamed El Kassas, Ashraf Tabll, Guofeng Cheng, William E Delaney, Masamichi Muramatsu, Takaji Wakita

AASLD 2018年

もっとみる

担当経験のある科目(授業)

所属学協会

共同研究・競争的資金等の研究課題

キネシン-輸送基質相互作用特異性の解明と新規ウイルス感染阻害アプローチ

日本学術振興会科学研究費助成事業基盤研究(C) 2023年4月 - 2026年3月

アリフセインハッサン
レポーターHBVを駆使したB型肝炎ウイルス増殖機構の解析と創薬ターゲットの探索・同定に資する研究

AMED 2022年4月 - 2025年3月

Ikuo Shoji
B型肝炎モデル動物を用いたHBV持続感染根治治療の開発

AMED 2022年4月 - 2025年3月

Kazuaki Chayama
HBV cccDNAの産生と維持に関わるウイルスおよび宿主因子の探索

AMED 2022年4月 - 2025年3月

Takanobu Kato

産業財産権

特許WO/2012/133156 METHOD FOR PRODUCING EPITHELIAL STEM CELLS

アリフセインハッサン

アリフセインハッサン

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

受賞

論文

MISC

講演・口頭発表等

担当経験のある科目(授業)

所属学協会

共同研究・競争的資金等の研究課題

産業財産権

メニュー

共著者の一覧