2013
Identification and characterization of an inhibitor of trichothecene 3-O-acetyltransferase, TRI101, by the chemical array approach.
Bioscience, Biotechnology, and Biochemistry
- Volume
- 77
- Number
- 9
- First page
- 1958
- Last page
- 1960
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1271/bbb.130153
- Publisher
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
Trichothecene 3-O-acetyltransferase (TRI101) is an indispensable enzyme for the biosynthesis of trichothecenes, a group of mycotoxins produced by Fusarium graminearum. In this study, an inhibitor of TRI101 was identified by chemical array analysis using compounds from the RIKEN Natural Products Depository (NPDepo) library. Although the addition of the identified enzyme inhibitor to the fungal culture did not inhibit trichothecene production, it can serve as a candidate lead compound in the development of a mycotoxin inhibitor that inactivates fungal defense mechanisms.
- Link information
- ID information
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- DOI : 10.1271/bbb.130153
- ISSN : 0916-8451
- CiNii Articles ID : 10031202751
- CiNii Books ID : AA10824164
- ORCID - Put Code : 31436136
- Pubmed ID : 24018674