論文

査読有り 筆頭著者 責任著者 国際誌
2008年12月19日

Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells.

Biochemical and biophysical research communications
  • Rie Watanabe
  • ,
  • Zhen-Ping Shen
  • ,
  • Kinsuke Tsuda
  • ,
  • Yuichiro Yamada

377
3
開始ページ
867
終了ページ
72
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2008.10.074
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Activins regulate pancreatic development, differentiation and insulin secretion. Activin receptor-like kinase 7 (ALK7) has been identified as a receptor for Nodal and Activin AB and B, and is expressed in pancreatic islets and beta-cell lines. In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway. A conserved Smad binding element was related to the promoter activation. Phosphorylated Smad2/Smad3 and PDX-1 were bound to insulin gene with Nodal and Activin AB, and the phosphorylated Smad2/Smad3 interacted with PDX-1. These results indicate that one of the direct target genes of Nodal and Activin AB signals is the insulin gene in pancreatic beta-cells and that PDX-1 is directly involved in the ALK7-Smad pathway.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2008.10.074
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18951876
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000261458900025&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.bbrc.2008.10.074
  • ISSN : 0006-291X
  • PubMed ID : 18951876
  • Web of Science ID : WOS:000261458900025

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