2008年12月19日
Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells.
Biochemical and biophysical research communications
- ,
- ,
- ,
- 巻
- 377
- 号
- 3
- 開始ページ
- 867
- 終了ページ
- 72
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2008.10.074
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Activins regulate pancreatic development, differentiation and insulin secretion. Activin receptor-like kinase 7 (ALK7) has been identified as a receptor for Nodal and Activin AB and B, and is expressed in pancreatic islets and beta-cell lines. In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway. A conserved Smad binding element was related to the promoter activation. Phosphorylated Smad2/Smad3 and PDX-1 were bound to insulin gene with Nodal and Activin AB, and the phosphorylated Smad2/Smad3 interacted with PDX-1. These results indicate that one of the direct target genes of Nodal and Activin AB signals is the insulin gene in pancreatic beta-cells and that PDX-1 is directly involved in the ALK7-Smad pathway.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bbrc.2008.10.074
- ISSN : 0006-291X
- PubMed ID : 18951876
- Web of Science ID : WOS:000261458900025