飯嶋徹 (Toru Iijima) - マイポータル

基本情報

所属: 東京大学大学院薬学系研究科附属創薬機構特任准教授

学位: 博士（薬学）

ORCID iD: https://orcid.org/0000-0001-8323-5523
J-GLOBAL ID: 202301015456470241
researchmap会員ID: R000055431

論文

Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor

Daisuke Iijima, Hiroshi Sugama, Yoichi Takahashi, Miki Hirai, Yuko Togashi, Jianshu Xie, Jingkang Shen, Ying Ke, Hidenori Akatsuka, Takayuki Kawaguchi …

Journal of Medicinal Chemistry 65(16) 10882-10897 2022年8月25日
Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors

Daisuke Iijima, Hiroshi Sugama, Nobumasa Awai, Yoichi Takahashi, Yuko Togashi, Tohru Takebe, Jianshu Xie, Jingkang Shen, Ying Ke, Hidenori Akatsuka …

ACS Medicinal Chemistry Letters 13(8) 1351-1357 2022年8月11日
新規非ステロイド型ミネラロコルチコイド受容体拮抗薬apararenone（MT-3995）の創製

飯嶋徹, 赤塚英則, 武富啓

MEDCHEM NEWS 32(3) 154-159 2022年8月1日
Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist

Toru Iijima, Makoto Katoh, Kei Takedomi, Yasuo Yamamoto, Hidenori Akatsuka, Naritoshi Shirata, Akito Nishi, Misae Takakuwa, Yoshinori Watanabe, Hitomi Munakata …

Journal of Medicinal Chemistry 2022年6月23日
新規レニン阻害薬SPH3127の創製～次世代レニン阻害薬を目指して～

飯嶋大輔, 須釜寛, 平井未希, 高橋陽一, 飯嶋徹

MEDCHEM NEWS 30(3) 120-125 2020年8月1日
Synthesis and biological evaluation of p-carborane bisphenols and their derivatives: Structure-activity relationship for estrogenic activity

Ogawa, T., Ohta, K., Iijima, T., Suzuki, T., Ohta, S., Endo, Y.

Bioorganic and Medicinal Chemistry 17(3) 2009年
Novel retinoid X receptor (RXR) antagonists having a dicarba-closo- dodecaborane as a hydrophobic moiety

Ohta, K., Iijima, T., Kawachi, E., Kagechika, H., Endo, Y.

Bioorganic and Medicinal Chemistry Letters 14(23) 2004年
Potent estrogen agonists based on carborane as a hydrophobic skeletal structure: A new medicinal application of boron clusters

Endo, Y., Iijima, T., Yamakoshi, Y., Fukasawa, H., Miyaura, C., Inada, M., Kubo, A., Itai, A.

Chemistry and Biology 8(4) 2001年
Structure-activity study of retinoid agonists bearing substituted dicarba-closo-dodecaborane. Relation between retinoidal activity and conformation of two aromatic nuclei

Endo, Y., Iijima, T., Yaguchi, K., Kawachi, E., Inoue, N., Kagechika, H., Kubo, A., Itai, A.

Bioorganic and Medicinal Chemistry Letters 11(10) 2001年
Dicarba-closo-dodecaboranes as a Pharmacophore. Novel Potent Retinoidal Agonists.

Yasuyuki ENDO, Toru IIJIMA, Hiroyuki KAGECHIKA, Kiminori OHTA, Emiko KAWACHI, Koichi SHUDO

Chemical and Pharmaceutical Bulletin 47(4) 585-587 1999年
Dicarba-closo-dodecaboranes as a pharmacophore. Retinoidal antagonists and potential agonists

Iijima, T., Endo, Y., Tsuji, M., Kawachi, E., Kagechika, H., Shudo, K.

Chemical and Pharmaceutical Bulletin 47(3) 1999年
Potent estrogenic agonists bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore

Endo, Y., Iijima, T., Yamakoshi, Y., Yamaguchi, M., Fukasawa, H., Shudo, K.

Journal of Medicinal Chemistry 42(9) 1999年
Estrogenic antagonists bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore

Endo, Y., Yoshimi, T., Iijima, T., Yamakoshi, Y.

Bioorganic and Medicinal Chemistry Letters 9(24) 1999年
Structure-activity study of estrogenic agonists bearing dicarba-closo- dodecaborane. Effect of geometry and separation distance of hydroxyl groups at the ends of molecules

Endo, Y., Iijima, T., Yamakoshi, Y., Kubo, A., Itai, A.

Bioorganic and Medicinal Chemistry Letters 9(23) 1999年
Efficient synthesis and gastric (H⁺/K⁺)-ATPase-inhibitory activity of 2-aryl-4,5-dihydro-1H-thieno[3,2-e]benzimidazoles

Homma, K., Watanabe, T., Iijima, T., Yato, M., Matsuki, K., Noto, T., Ishida, A.

Chemical and Pharmaceutical Bulletin 45(12) 1997年
Location of two photoaffinity-labeled sites on the ligand-binding domain of retinoic acid receptor α

Sasaki, T., Shimazawa, R., Sawada, T., Iijima, T., Fukasawa, H., Shudo, K., Hashimoto, Y., Iwasaki, S.

Biological and Pharmaceutical Bulletin 19(5) 1996年
Determination of the photoaffinity-labeled site on the ligand-binding domain of retinoic acid receptor α

Sasaki, T., Shimazawa, R., Sawada, T., Iijima, T., Fukasawa, H., Shudo, K., Hashimoto, Y., Iwasaki, S.

Biochemical and Biophysical Research Communications 207(1) 1995年
Retinobenzoic Acids. 6. Retinoid Antagonists with a Heterocyclic Ring

Laurence Eyrolles, Hiroyuki Kagechika, Emiko Kawachi, Hiroshi Fukasawa, Tohru Iijima, Youko Matsushima, Yuichi Hashimoto, Koichi Shudo

Journal of Medicinal Chemistry 37(10) 1508-1517 1994年5月
Expression of the Ligand-Binding Domain-Containing Region of Retinoic Acid Receptors α, β and γ in Escherichia coli and Evaluation of Ligand-Binding Selectivity

Fukasawa, H., Iijima, T., Kagechika, H., Shudo, K., Hashimoto, Y.

Biological and Pharmaceutical Bulletin 16(4) 1993年