1998年
The organization of the thalamostriatal projection from the lateral posterior thalamic nuclear complex (LP) in the pigmented rat
Neurobiology
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- ,
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- 巻
- 6
- 号
- 3
- 開始ページ
- 273
- 終了ページ
- 294
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
We investigated the thalamostriatal projection of the rat using biotinylated dextran amine (BDA) and wheat-germ agglutinin horseradish peroxidase (WGA-HRP). To obtain the patch/matrix compartments of the striatum (ST), we used μ-opioid receptor (MOR) immunoreaction labeling. Thus, an MOR- positive 'patch' was indicated by a darkly stained spot, while the MOR- negative 'matrix' was displayed as a non-immunoreactive region. A small injection of BDA was made in a subregion of the lateral posterior thalamic nucleus (LP). The LP-ST fibers originated in all subregions of LP and terminated in the dorsocaudal portion of ST, where the corticostriatal fibers from the visual cortex terminate (Serizawa et al. 1994). These LP-ST fibers and terminals were concentrated in the MOR-negative matrix compartment. Electron microscopic observations showed that the LP-ST terminals made asymmetrical synaptic contacts mainly (70%, n=30) with the dendritic spines of the presumptive ST-output neurons, and fewer (30%) contacted dendritic shafts. The present results provide anatomical support for the contention that ST-output spiny neurons of the matrix that project to the pars reticulata of the substantia nigra or globus pallidus, may be influenced directly by the LP-ST projection.
- リンク情報
- ID情報
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- ISSN : 1216-8068
- PubMed ID : 9778648
- SCOPUS ID : 0032453147