2006年9月
Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking
ANTIOXIDANTS & REDOX SIGNALING
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- 巻
- 8
- 号
- 9-10
- 開始ページ
- 1891
- 終了ページ
- 1896
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1089/ars.2006.8.1891
- 出版者・発行元
- MARY ANN LIEBERT, INC
Thioredoxin-1 (TRX) is a small redox-active protein with antioxidative effects and redox-regulating functions. Cigarette smoking is a major etiological factor in the pathogenesis of a variety of diseases and recruits systemic immune and inflammatory responses. This report demonstrates that TRX attenuates the systemic inflammatory responses induced by cigarette smoking. The mRNA expressions of tumor necrosis factor alpha (TNF-alpha) and macrophage migration inhibitory factor (MIF) were suppressed in the spleen of TRX over-expressing transgenic mice (TRX-tg) exposed to cigarette smoking, compared with control C57BL/6 mice. In addition, protein carbonylation, a marker of cellular protein oxidation, was enhanced by cigarette smoking in the tissues of heart and liver in control mice more than in TRX-tg mice. These findings suggest that TRX may suppress the systemic inflammatory responses against cigarette smoking.
- リンク情報
- ID情報
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- DOI : 10.1089/ars.2006.8.1891
- ISSN : 1523-0864
- eISSN : 1557-7716
- PubMed ID : 16987041
- Web of Science ID : WOS:000240523900043