論文

査読有り 責任著者
2018年6月1日

Cladosporamide A, a new protein tyrosine phosphatase 1B inhibitor, produced by an Indonesian marine sponge-derived Cladosporium sp.

Journal of Natural Medicines
  • Henki Rotinsulu
  • ,
  • Hiroyuki Yamazaki
  • ,
  • Shino Sugai
  • ,
  • Natsuki Iwakura
  • ,
  • Defny S. Wewengkang
  • ,
  • Deiske A. Sumilat
  • ,
  • Michio Namikoshi

72
3
開始ページ
779
終了ページ
783
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s11418-018-1193-y
出版者・発行元
Springer Tokyo

Cladosporamide A (1), a new protein tyrosine phosphatase (PTP) 1B inhibitor, was isolated together with a known prenylated flavanone derivative (2) from the culture broth of an Indonesian marine sponge-derived Cladosporium sp. TPU1507 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on 1D and 2D NMR data. Compound 1 modestly inhibited PTP1B and T-cell PTP (TCPTP) activities with IC50 values of 48 and 54 μM, respectively. The inhibitory activity of 2 against PTP1B (IC50 = 11 μM) was approximately 2-fold stronger than that against TCPTP (IC50 = 27 μM).

リンク情報
DOI
https://doi.org/10.1007/s11418-018-1193-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29508256
URL
http://europepmc.org/abstract/med/29508256
URL
http://orcid.org/0000-0002-1540-7255
ID情報
  • DOI : 10.1007/s11418-018-1193-y
  • ISSN : 1861-0293
  • ISSN : 1340-3443
  • ORCIDのPut Code : 43728168
  • PubMed ID : 29508256
  • SCOPUS ID : 85045153951

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