2018年6月1日
Cladosporamide A, a new protein tyrosine phosphatase 1B inhibitor, produced by an Indonesian marine sponge-derived Cladosporium sp.
Journal of Natural Medicines
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 72
- 号
- 3
- 開始ページ
- 779
- 終了ページ
- 783
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s11418-018-1193-y
- 出版者・発行元
- Springer Tokyo
Cladosporamide A (1), a new protein tyrosine phosphatase (PTP) 1B inhibitor, was isolated together with a known prenylated flavanone derivative (2) from the culture broth of an Indonesian marine sponge-derived Cladosporium sp. TPU1507 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on 1D and 2D NMR data. Compound 1 modestly inhibited PTP1B and T-cell PTP (TCPTP) activities with IC50 values of 48 and 54 μM, respectively. The inhibitory activity of 2 against PTP1B (IC50 = 11 μM) was approximately 2-fold stronger than that against TCPTP (IC50 = 27 μM).
- リンク情報
- ID情報
-
- DOI : 10.1007/s11418-018-1193-y
- ISSN : 1861-0293
- ISSN : 1340-3443
- ORCIDのPut Code : 43728168
- PubMed ID : 29508256
- SCOPUS ID : 85045153951