論文

2015年8月

Reduction of interleukin-10 production by B cells in intractable toxic epidermal necrolysis

JOURNAL OF DERMATOLOGY
  • Amiko Hakuta
  • ,
  • Hiroyuki Fujita
  • ,
  • Miwa Kanaoka
  • ,
  • Midori Watanabe
  • ,
  • Kanako Izumi
  • ,
  • Tomoya Watanabe
  • ,
  • Noriko Komitsu
  • ,
  • Munenari Itoh
  • ,
  • Katsumi Tanito
  • ,
  • Yukitoshi Takahashi
  • ,
  • Michiko Aihara

42
8
開始ページ
804
終了ページ
808
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/1346-8138.12909
出版者・発行元
WILEY-BLACKWELL

Several interleukin (IL)-10 producing B-cell subsets have been identified recently. However, few studies have examined the role of them in toxic epidermal necrolysis (TEN). We describe a 41-year-old woman with TEN who had B-cell lymphoma and a history of treatments including B-cell depletion therapy. Her re-epithelization was still ongoing after 7months, despite treatments. To investigate her immune system, we compared cytokine and chemokine production from B cells and non-B cells isolated from the patient and another non-lymphoma TEN patient. IL-10 production from B cells decreased in the patient compared with the control TEN-only patient. Cytokine and chemokine levels from non-B cells involved in inflammation were elevated in the patient compared with the control patient. In conclusion, this study demonstrates that IL-10 from B cells as well as regulatory T cells is critical in the pathogenesis of TEN, and that B-cell dysfunction based on B-cell lymphoma and B-cell depletion therapy may be involved in the intractability of TEN.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1111/1346-8138.12909
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000358683500007&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84937972185&origin=inward

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