論文

査読有り 国際誌
2020年9月

Increased level of high mobility group box 1 in the serum and skin in patients with generalized pustular psoriasis.

The Journal of dermatology
  • Tomoya Watanabe
  • ,
  • Yukie Yamaguchi
  • ,
  • Yuko Watanabe
  • ,
  • Naoko Takamura
  • ,
  • Michiko Aihara

47
9
開始ページ
1033
終了ページ
1036
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/1346-8138.15467

High-mobility group box 1 (HMGB-1) is a highly abundant pro-inflammatory protein associated with the pathogenesis of inflammatory and autoimmune diseases. HMGB-1 expression level increases in patients with psoriasis vulgaris (PV). However, HMGB-1 expression in patients with generalized pustular psoriasis (GPP) is unknown. In this study, we investigated HMGB-1 expression in GPP. HMGB-1 expression levels were examined in the skin and serum of patients with GPP, PV, atopic dermatitis (AD) and healthy controls (HC) using enzyme-linked immunosorbent assay and immunohistochemistry. The elevation in HMGB-1 expression was significantly higher in GPP patients than in PV, AD and HC patients. In addition, patients with GPP had elevated serum HMGB-1 levels compared with those with AD and HC. Furthermore, serum HMGB-1 levels were significantly decreased after systemic treatment. In the correlation analysis, a significant positive correlation was detected between serum HMGB-1 levels and the Japanese severity score for GPP. HMGB-1 may be involved in the pathogenesis of GPP and can be useful to evaluate disease severity and the effectiveness of GPP treatment.

リンク情報
DOI
https://doi.org/10.1111/1346-8138.15467
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32613742

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