2020
Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue
In Vivo
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- Volume
- 34
- Number
- 2
- First page
- 615
- Last page
- 622
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.21873/invivo.11815
- Publisher
- Anticancer Research USA Inc.
BACKGROUND/AIM: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss. MATERIALS AND METHODS: Male Fischer 344 rats (8 weeks old) were randomized to four groups; the baseline group immediately sacrificed, the control group fed with normal powdered food for 8 weeks, and the experimental groups fed with powdered food containing 0.62% or 1.36% coffee components for 8 weeks. RESULTS: Alveolar bone loss and gingival level of 8-hydroxydeoxyguanosine were significantly lower in the 1.36% coffee group than in the control group. Nuclear factor erythroid 2-related factor 2 translocation to the nucleus was significantly higher in the 1.36% coffee group than in the control group. CONCLUSION: Continuous intake of 1.36% coffee could prevent age-related oxidative stress in the periodontal tissue and alveolar bone loss, possibly by up-regulating the Nrf2 signaling pathway.
- Link information
- ID information
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- DOI : 10.21873/invivo.11815
- ISSN : 0258-851X
- eISSN : 1791-7549
- Pubmed ID : 32111761
- Pubmed Central ID : PMC7157847