Papers

Peer-reviewed International journal
2020

Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue

In Vivo
  • TERUMASA KOBAYASHI
  • ,
  • TAKAYUKI MARUYAMA
  • ,
  • TOSHIKI YONEDA
  • ,
  • HISATAKA MIYAI
  • ,
  • TETSUJI AZUMA
  • ,
  • TAKAAKI TOMOFUJI
  • ,
  • DAISUKE EKUNI
  • ,
  • MANABU MORITA

Volume
34
Number
2
First page
615
Last page
622
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.21873/invivo.11815
Publisher
Anticancer Research USA Inc.

BACKGROUND/AIM: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss. MATERIALS AND METHODS: Male Fischer 344 rats (8 weeks old) were randomized to four groups; the baseline group immediately sacrificed, the control group fed with normal powdered food for 8 weeks, and the experimental groups fed with powdered food containing 0.62% or 1.36% coffee components for 8 weeks. RESULTS: Alveolar bone loss and gingival level of 8-hydroxydeoxyguanosine were significantly lower in the 1.36% coffee group than in the control group. Nuclear factor erythroid 2-related factor 2 translocation to the nucleus was significantly higher in the 1.36% coffee group than in the control group. CONCLUSION: Continuous intake of 1.36% coffee could prevent age-related oxidative stress in the periodontal tissue and alveolar bone loss, possibly by up-regulating the Nrf2 signaling pathway.

Link information
DOI
https://doi.org/10.21873/invivo.11815
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32111761
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157847
URL
https://syndication.highwire.org/content/doi/10.21873/invivo.11815
ID information
  • DOI : 10.21873/invivo.11815
  • ISSN : 0258-851X
  • eISSN : 1791-7549
  • Pubmed ID : 32111761
  • Pubmed Central ID : PMC7157847

Export
BibTeX RIS